DNA Dimensions Header Joy McEntire
Joy McEntire
Medical Intuitive ~ Health-for-Life Consultant ~ DNA Communicator ~ Based on Your Unique DNA, Genes, Body, & More ~ Finding Amazing Answers
Case Studies
I like to help people find amazing, yet very practical answers to their medical questions, and I often find the most fascinating core pieces right within the genes. Each and every single one of these case studies is unique and (to me) fascinating.
Before reading the Case Studies below, PLEASE read the Intro Page first!
Specificially, please read the Disclaimer at the bottom of the intro page.
At the moment, I'm only just beginning to publish these. There are many, many more... and there are NO "ordinary" consultations. I could have started with ANY of them, because they are all as fascinating as these that I have chosen to begin with.
You'll find a lot of helpful info on the Intro Page .
For example, you'll learn about your unique "recipe book", and how individuals often make unique and sometimes funny substitutions for "ingredients" they don't happen to have on hand.
You'll learn about the programs I use, and why... and why I include so many links ... and there's much more.
If you're in a hurry, though, the short version is that we're simply looking for the places where someone's DNA has sequenced work-arounds that are impacting their life and their health in the present-day.
So for the case studies, here goes...
(A note added November 18, 2017: I've just moved, and the past few months have gone by far too quickly. Moving is a really big deal!!! It also took a lot of my time to get my new website up and going. I have MANY many more case studies to publish, and they just continue to get more interesting! It may be January 2018 before things settle down enough to begin publishing again. Please be patient, as my time is limited. Those published here are just "a teaser" of what is to come. For now, happy reading!)
Case Studies
(Please note that you can also quickly skip to the next consultation by clicking on the little arrow at the right of each entry…
   … that will let you see just the titles at a glance.)

 
   10/19/2016  ~  … and is her protein shapely?
 
 

10/19/2016

… and is her protein shapely?
Consultation for SweetLillette, a 58-year old female

This consultation is one of those that came well before I knew that I would be publishing my notes, so there are many "just quick notes", without as much of the elaboration of the information, links, and more, as some of the subsequent consultations.

Still, there is helpful information here...

SweetLillette brought along some doctor's visit notes and lab results from a very recent doctor's visit.

I have found that sometimes, even when the values are within normal ranges, I will often be very aware that something is "incorrect". So there were several of her blood test results that were "within normal ranges" but still "off" nevertheless.

For starters, her TSH  was coming up. TSH is Thyroid-stimulating hormone:
"Thyroid-stimulating hormone (also known as thyrotropin, thyrotropic hormone, TSH, or hTSH for human TSH) is a pituitary hormone that stimulates the thyroid gland to produce thyroxine (T4), and then triiodothyronine (T3) which stimulates the metabolism of almost every tissue in the body."
However, this was only a "clue" to where we needed to actually look. The text that stands out as "the next clue" is under the heading "Physiology", under "Hormone levels":
"The hypothalamus, in the base of the brain, produces thyrotropin-releasing hormone (TRH). TRH stimulates the pituitary gland to produce TSH."
It's actually the TRH, or Thyrotropin-releasing hormone that's the issue.
"Thyrotropin-releasing hormone (TRH), also called thyrotropin-releasing factor (TRF) or thyroliberin, is a releasing hormone, produced by the hypothalamus, that stimulates the release of thyrotropin (thyroid-stimulating hormone or TSH) and prolactin from the anterior pituitary. It is a tropic, tripeptidal hormone."
The first diagram at the top right-hand side of the page shows the structural formula of TRH.

In SweetLillette, the structure was off at the bottom of the structure, and was somehow resulting in stimulation of muscles in the pectoral muscle groups. Taking the time to look at the chemical structure of TRH was enough to reset it for now.

Next, albumin was coming up as being "off".

"The albumins ... are a family of globular proteins, the most common of which are the serum albumins."
... and...
"Albumin binds to the cell surface receptor albondin."
What's coming up is that the albondin doesn't work well at this time, in SweetLillette.

Wikipedia doesn't have any information about Albondin, other than that it is a cell receptor that binds albumin. If I were able to see what the "shape" of the protein is meant to be, we could figure out how to adjust this, but for now, it's enough to understand that it is out of balance ... because too many other proteins are not functioning correctly.

Just a quick note about the shape of the proteins:
It's the SHAPE of the protein that makes it function.
There are some very sophisticated techniques currently used that enable us to simulate (or "photograph") the shapes of proteins. Whenever the shape of a protein is produced as an computer-generated diagram, it's a "visual" indicating what the protein looks like. These "protein shapes" are actually exceptionally helpful, as they give us "the inside scoop" on what the body is actually trying to accomplish.

If the shape of the protein is off, it can't do its job. It's that simple.

Please understand that "proteins rule!" Having adequate supplies of correctly formed proteins allows the body to function much better.

When someone doesn't have ENOUGH protein, or insufficient quantities of pretty much any of the amino acids, which are the building blocks of the proteins, the body has to try to scrape together every bit of advantage or work-around that it can manage...

Remember, DNA is an instruction manual, and it is recipes for building proteins... and the DNA recipes are all about running the body, including trying to correct the underlying infrastructure of the core components of the cells, again, using protein.

So if you don't have the necessary ingredients, your DNA can read off instructions all day long (and all night too!), and it keeps on going in circles! (What came first? The DNA, or the amino acids that the DNA calls for? Was it the chicken, or the egg?)

So SweetLillette is trying SO very hard to repair her body, but can't, because the most basic proteins aren't there. She's been in a "catch 22" situation for a very long time.

For the past several years, she has been trying to supplement by using a pea protein powder. Initially, that was very helpful, but lately, it's been causing stresses for her, as it not only couldn't provide some of the essential amino acids that she needed, but it even began interfering with those she WAS processing okay. (She has eaten very little animal food during her lifetime, but has had dairy often, which has supplied some of the amino acids she needs.)

She also has numerous "cycles" that greatly limit what she can eat, because she can't digest fats well, and some foods trigger migraine headaches, and there are many other bits that all put together a picture of "her body doesn't know how to break the cycle". Because of these cycles, she hasn't been getting enough nutrients overall, and her weight is on the exceptionally-way-far-too-low side.

She is an "A" blood type, and therefore, doesn't easily digest animal protein, which is part of the conundrum. She has eaten what it is that "agrees" with her.

So the albumin is simply one of the issues that her body is facing. It's not so much that we need to "fix the albumin", as that the albumin in simply one of her bigger "pointers" to the underlying "quality-of-protein" issues.

Recently, I suggested that she stop using the pea protein supplement, as it was actually causing more difficulties at this time, and interfering with many different things in her body. Since she stopped using it, her protein base has been in the process of improving.

She has also been willing to add a bit of fish to her diet, for more protein. I've given her a "work-around" that allows her to begin digesting some of the animal proteins. (My work-around is "a secret", but one that almost everyone who needs it really enjoys... )

She is able to eat more foods at the present time because of this, and it also helps her to bypass the migraine headaches significantly. Overall, it allows her to include nutrients that she has been "without" for a quite a long time. (Maybe one of these days I'll share my "secret", as I'm pretty sure it will help just about anyone who needs it.)

In any case, eating more protein can help SweetLillette's DNA to function more effectively, so that many other things can also re-sequence better.

Back to her blood work:

In her last blood test, SweetLillette's Vitamin B12 value had also come back as being far too high. SweetLillette had been supplementing with vitamin B12.

Interestingly enough, although the value was far too high, something else related to the B12 was way off, so we looked it up:
"Vitamin B12, also called cobalamin, is a water-soluble vitamin that has a key role in the normal functioning of the brain and nervous system via the synthesis of myelin (myelinogenesis), and the formation of red blood cells. It is one of eight B vitamins. It is involved in the metabolism of every cell of the human body, especially affecting DNA synthesis, fatty acid and amino acid metabolism."
The chemical structure of vitamin B12 is shown in the diagram at the right-hand side of the page: https://en.wikipedia.org/wiki/Vitamin_B12#/media/File:Cobalamin.png

In SweetLillette, the vitamin B12 is formed completely wrong!

So the value was far too high, but the structure wasn't anything close to what it should look like. We spent some time with the diagram, as it helps SweetLillette's body to remember how to make it correctly.

I have almost always found this to be the case:
When we supplement with something, the form we end up with in our bodies isn't at all like it would be without the supplement. The chemistry doesn't "translate" correctly... and then our bodies have to make "work-arounds".
Vitamin B12 is usually taken in mcg (micrograms), and often sublingually, and can be taken in fairly significant doses, such as 5000 mcg, as was the case here. I suggested a different version: a 1000 mcg version... a much smaller dosage but using a "delayed release" version. (Vitacost makes one under their own brand name, which is what we used.) The delayed-release version will help her to digest it correctly, and form her own better again.

We also  looked at the CBWD3  gene on chromosome 9: https://www.omim.org/search/?index=geneMap&start=1&search=CBWD3&limit=10
Gene/Locus: CBWD3
Gene/Locus Name: Cobalamin synthetase W domain-containing protein 3
Chromosome: 9
Genomic Start: 9:68,232,436
Cyto Location: 9q21.11
This gene is incorrectly formed in SweetLillette, in other words, it isn't doing its job.


In looking at this, we can find many corrections that SweetLillette has been needing for quite some time.

Her vitamin B12 will begin to correct itself now, because we have looked at the correct configuration.

Back to the blood work again... the next thing that was off was the Chloride. The "level" of Chloride was nicely within the normal values, but something was off, nevertheless.

"[Chloride] is an essential electrolyte located in all body fluids responsible for maintaining acid/base balance, transmitting nerve impulses and regulating fluid in and out of cells."
SweetLillette mentioned that whenever she is given chloride (e.g., as potassium chloride with a diuretic, and also just regular table salt), she retains fluid; It's interstitial fluid that she's retaining.

Just looking at the chloride page allows SweetLillette's chloride to begin functioning. Okay, so chloride is just basic chemistry, right? It's a simple Cl-, a negatively charged ion. That should always work correctly, right?

Not necessarily, depending on the individual's other bloodwork. "Reactions" are happening, but her entire system is too alkaline, which affects much of SweetLillette's very core chemistry...

... and our chemistry affects the biology. Big-time!

Having looked at the Chloride, some of those reactions will begin to work a lot more "robustly". When we've rechecked on this, several months down the road, her chloride is "normal", as is her gene for Cystic Fibrosis now... but more about that another time!

(published 08/30/2017)
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   11/19/2016  ~  Two genes, from different branches of the family…
 
 

11/19/2016

Two genes, from different branches of the family…
Consultation for ChocolateLover, a 47-year old female

During this consultation, we began by looking at the cookware that ChocolateLover has been using throughout her life, as that has been an area of significance for several other individuals lately, and I was looking for correlations, and in doing that, helping the genes to find some "Corrected versions."

There were several issues related to cookware, and we began by following the threads to one of them:  

Apparently, aluminum cookware had been used when ChocolateLover was young.

... and apparently, this had left aluminum in the brain, as well as in other parts of the body.

This was coming up as is core to ChocolateLover's memory... which she has always said was a challenge for her. She has often said she needs help remembering things.

In many individuals, I have found that the genes affecting aluminum are on chromosome 8, however, in ChocolateLover, aluminum processing was sitting on chromosome 10, and was having a bigger effect than the chromosome 8 individuals.

ChocolateLover's genes are very efficient at putting away the aluminum, i.e., taking it out of the key systems in the body, and managing that well, however, the aluminum is not actually being taken out of the body. For that to happen, her kidneys would need to be overhauled first.

We looked briefly at chromosome 10, but didn't spend much time there. (The moment I am aware of something, however, the individual often "finds the correction", and this was the case here. So we didn't delve into the details, but rather, moved on. As well, at the time of this consultation, I wasn't yet writing the notes to include all of the links and information in a way that would allow me to publish the consultations in a concise way...)

So we moved on.

What I have found, is that everyone has one or two chromosomes that have many issues on them... more so than the rest of their chromosomes. ChocolateLover's was chromosome 15. There was something around age 12, which affected everything from the starting point of chromosome 15.

It helps to understand that often, when one gene is incorrect, there are many other things on the same area of that chromosome that are also affected.

So to begin with, DNA reads everything going one way, and it reads along in three-letter codes that literally tell the body, "put together this amino acid, with this next amino acid, followed by this amino acid again, etc.

If something goes missing, then the DNA isn't calling for the right amino acids any more, or something can get mixed up in other ways as well, which can then throw everything else off... and since genes just "run together" along the chromosome, one individual gene isn't isolated, and more can be affected...

... and because genes are recipes for proteins and enzymes, if the "unruly" gene makes an enzyme that is part of several other processes, then those processes may not work nicely, and the body just can't figure out how to correct it.

(Please note that everyone's DNA is really good at proofreading, but occasionally, it doesn't know just how to undo a change, especially when many changes come all at the same time.)

Anyway, since chromosome 15 was coming up for ChocolateLover as having some "issues", that's where we began looking.

Another thing that ChocolateLover has mentioned numerous times is that "anxiety that seems to be continuously present"... and somehow, this chromosome 15 was coming up related to that anxiety.

I began by scanning through genes on chromosome 15. However, even just scanning the first page of the gene map actually brought up a great deal of anxiety energy. (This was really unusual...)

I didn't get very far! The first gene that came up was the second gene listed for chromosome 15! It is called AUTS4 and is labeled as "Autism, susceptibility to".
Chromosome: 15
Genomic Start: 15:19,000,000
Cyto Location:  15q11
Gene/Locus: AUTS4
Gene/Locus Name: Autism, susceptibility to, 4
Gene/Locus MIM Number: 608636
While ChocolateLover doesn't actually feel like an autistic individual to me, that "label" had come up repeatedly before for her, and she has commented many times about being challenged in connecting with other people.

Sometimes it’s not convenient to go head-first into something big, and if several more genes are added to the sequence (no pun intended!), then the bigger picture changes as well, but far more smoothly. That happened to be the case here.

So next, I looked at another gene on Chromosome 15 that was connected to the AUTS4 gene for ChocolateLover (at location 15q11.2), which underlies the bigger picture... but which felt much nicer to work with at this point, the C15DELq11.2 gene:
Chromosome: 15
Genomic Start: 15:20,500,000
Cyto Location: 15q11.2
Gene/Locus: DEL15q11.2, C15DELq11.2
Gene/Locus Name: Chromosome 15q11.2 deletion syndrome
Gene/Locus MIM Number: 615656
Comments: deleted region spans 300-500kb between BP1 and BP2
This really was the gene we needed!

As I was trying to write the explanation above about why sometimes more things are "off" on a given chromosome, the information that kept coming was that whatever this was for ChocolateLover, it wasn't "a small thing" at all.

... and here, you can see that there is a whole gene that says "I delete" (or, "I move things around, and the net result is 'it's gone'.")
It's all there, in the Gene/Locus Name given to these genes: "Chromosome 15q11.2 deletion syndrome", even without reading the "Comments".


So as we checked on this information, many things began changing back to a nice and corrected version again. It sometimes takes time for this to happen, but seeing the corrections (or sometimes just the variations, or alleles), can be sufficient.

This will continue to correct itself as time goes on, and it already has (as I'm writing up this info in July, 2017) This was a start of many new things, i.e., "One gene, many different systems affected."

To help understand better, perhaps: This C15DELq11.2 gene wasn't the part that was deleted... rather, there is something related to this gene, which seems to cause deletions in DNA base pairs. If you have this gene, are you in trouble? No, not at all.
Genes are not there to cause disease! (This is a sentiment echoed by almost all scientists!)

Rather, genes are named based on the problems they are responsible for when something in that particular gene is not working correctly.
So it feels like there might have been something related to the gene being switched on or off, incorrectly, which meant it couldn't do its job, and resulted in some base pairs being deleted, which caused anxiety... not because the base pairs were deleted (yes, that could have been rather worrisome, but chances are that ChocolateLover wasn't aware of it!)...  but rather, because of the functionality that resulted (or couldn't happen) when those base pairs were deleted.

That was it for today... one big thing is great.

However, the whole time throughout the consultation today, something about “Chondroitin” kept coming up.  So eventually, I paid attention to that.

It may help to know, first, that this client has had very great ongoing pain, deep inside the physical, and has tried many numerous ways of trying to deal with it, and some of them work temporarily, and then the body slips back into the previous patterns.

When I looked up chondroitin, I was able to follow the links through some core pieces for ChocolateLover.

I'm not exactly sure what links we followed, but we ended up at Wikipedia's “Immunoglobulin domain” page: https://en.wikipedia.org/wiki/Immunoglobulin_domain

"Immunoglobulin domain" apparently had something to do with ChocolateLover's history.

There were two main things:

First, under the heading "Examples", the NCAM1 gene came up.
So we looked up the NCAM1 gene in the gene map database:
Chromosome: 11
Genomic Start: 11:112,961,246
Cyto Location: 11q23.2
Gene/Locus: NCAM1, MSK39
Gene/Locus Name: Neural cell adhesion molecule 1  
Gene/Locus MIM Number: 116930
It is listed as one of several of the Immunoglobulin domain links, and also labeled “Neural cell adhesion molecule”. It was causing a big problem... It is present in everyone, but in ChocolateLover, it’s mutated somewhat, so that it’s her thoughts that are stressed... or anxious, if you like, as a result.

This was helpful, but when I did a search on "Chondroitin" in the gene map database, we found something that was much more helpful... and interestingly enough, the chondroitin gene that is "way off" was also on Chromosome 15... related to the big anxiety.

It was the ACAN gene, which is related to Aggrecan:
Chromosome: 15
Genomic Start: 15:88,803,441
Cyto Location: 15q26.1
Gene/Locus: ACAN, AGC1, CSPG1, MSK16, SEDK
Gene/Locus Name: Aggrecan (chondroitin sulfate proteoglycan-1, large aggregating proteoglycan, antigen identifies by monoclonal antibody A0122)
Gene/Locus MIM Number: 155760
Phenotype: Spondyloepimetaphyseal dysplasia, aggrecan type
There are actually several phenotypes listed, but the one that's most relevant just now, is the "Spondyloepimetaphyseal dysplasia, aggrecan type", this being one of several possible results of a mutated gene near this location.

There is more information available about the ACAN gene.
"Aggrecan (ACAN), also known as cartilage-specific proteoglycan core protein (CSPCP) or chondroitin sulfate proteoglycan 1, is a protein that in humans is encoded by the ACAN gene."
That is, if it is formed nicely, which it wasn't, yet, in ChocolateLover (but it is already... July 2017).

So the ACAN gene is related to "proteoglycan 1". This, however, then comes up as not quite the right piece yet... but proteoglycan 2 is.  (We're following a trail, remember?)

In the meantime, though, a piece that comes up as NECESSARY for us to put things together, is:
"Aggrecan is a proteoglycan, or a protein modified with large carbohydrates; the human form of the protein is 2316 amino acids long and can be expressed in multiple isoforms due to alternative splicing."
It turns out to be relevant that aggrecan has (exactly) 2316 amino acids.

Somehow, ChocolateLover has been making only partial amounts, and nowhere near 2316 amino acids.
Having this exact and specific information is like a piece of heaven... she may begin correcting another one of her big-time "off" recipes.

The info in Wikipedia also says:
“... Proteoglycans are also involved in binding cations (such as sodium, potassium and calcium) and water...”
Here, it’s the CALCIUM that comes up. It can’t move. It wasn't able to find a way to leave the body. (it’s not soluble yet... ) All because of the proteoglycans.

Hooray! We've found something we've needed... There will be more to look for, but this is a beginning.

Now it’s clear to me that ChocolateLover's chondroitin has the correct structure, but can't work right (yet), partly because the foundation is still not correct, related to the proteoglycans (... and there will still be another piece after that).

I found a “corrected version of chondroitin” for ChocolateLover in one of the various databases available, and ChocolateLover can begin using it now. (As this was one of the earlier consultations before I was keeping all of the links, I don't know exactly what it was we looked at, then. Now, however, there would be new chemistry, and more options, because there is greater movement of the calcium.)

So now, you'll learn that this chondroitin gene was one of the pieces of ChocolateLover's Lupus (which has been present for a long time).

What came up is that ChocolateLover received one set of recessive genes from one of her ancestors... which has been a part of the chondroitin issue (via her father... grandfather... great grandfather... great great grandfather)

... and then, there is another "bad copy" of a gene from another branch of her family that is part of the lupus puzzle for ChocolateLover (via her ... father... grandmother... great grandfather)

The two genes, from different branches of the family, came together in ChocolateLover, causing immune system challenges.

(published 07/19/2017)
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   11/19/2016  ~  Pots can be dangerous… and ''did you brush your teeth?''
 
 

11/19/2016

Pots can be dangerous… and "did you brush your teeth?"
Consultation for Peppermint, a 54-year old female

This was one of the earlier consultation where I hadn't yet kept track of all of the specific details so that someone could "follow the trail". However, I'll do my best to fill in the information...

I often check on the forms of "cookware" that individuals have used throughout various times of their lives, since it can have an impact on many things. There are several types of cookware that tend to wreak havoc in the genes, and even though that particular cookware may no longer be used, the genes are still impacted.

In looking at the cookware, I had been looking simply at which chromosomes were impacted, but at that point, I hadn't yet been looking for specific genes related to that.

So Peppermint said that as she was growing up, they had many different types of cookware, and that it had tended to be "whatever was the cheapest". That meant aluminum pots, and the older, cheapest type of teflon, and also enamel.

Aluminum cookware, as we now know, wasn't correct... and that has left some uncomfortable things.

Enamel cookware:
However, on this day, what was more significant was the enamel pots.
The problem with enamel is when it's broken or chipped, and that seems to happen fairly regularly, as it doesn't hold up with time.

I'm not completely sure, yet, why broken enamel is harmful, but it is, because for everyone who has used it, it comes up as having caused problems.

It could be that with cookware, we're using it day in and day out, and over time, the steady exposure to whatever the issue is, adds up.
"vitreous enamel is made by fusing melted glass particles to metal at high temperatures"
It seems that when the base metal is aluminum, it's especially harmful. (Enamel based on other types of metal are also not healthy, but I'm not exactly sure of the reason just now... only that our physical bodies beg for us to stay away from this!)

In any case, in Peppermint, chromosomes 11 and 18 have both been highly impacted by broken enamel. Somehow, it has left some form of chemicals in her body, and much of that within the nervous system.

Cookware and Flow of Electricity:
Much of what comes up with cookware is also related to "electricity". From what I am aware, it's related to the flow of the electricity.

The new pots that are made of stainless steel, with a thick aluminum core bottom, are fine. They distribute the electricity in a way that it's not harmful.

There are a few additional points, though:
Copper bottomed pots don't distribute the electricity in a comfortable way, and they come up as another "harmful" cookware.

... and the aluminum pots with the 3-ply aluminum core are great, but when it's a higher ply, like a 5-ply core or more, it again causes problems.
Please note, though: The flow of electricity is mostly related to the "coil burners" of the regular electric stoves. The flat-top stoves have a different flow as the coils are imbedded deeper down, below the pot, and so they are somewhat safer for people, even if the pots don't have the aluminum core bottom.

Gas stoves also don't have issues with electricity at all (obviously!) (although for some people, gas stoves also cause extreme issues), so there is a lot more versatility in the type of cookware used. If you have a gas stove, you can even cook with a glass pot, or corningware, or stainless steel pots without the aluminum core bottom, and you'll be just fine, at least as far as electricity is concerned!

Read that as "It's best to avoid glass cookware, etc., on the electric-coil type of stove.

Teflon and Non-stick Cookware:
Now we move on to the teflon cookware, which Peppermint's family used when she was young, and also since that time.

So for starters, as most people know now, the older versions of teflon were extremely difficult to process, and the body couldn't detox any of the material.

Let me begin by saying that teflon and other forms of non-stick are not "comfortable", and pose problems for our genes.
This is true even with the modern versions that are used to make non-stick cookware, although the manufacturers are constantly working on new technologies to make it safe. Most that are advertised as "green" or "safe" aren't there yet, as far as our human bodies concerned right now. Our genes are also slowly adapting, so with time, maybe we'll get there.
I've found with teflon and non-stick, that many individuals have some genes on both chromosome 8 and also chromosome 4 that need to be adjusted. Chromosome 4 seems to come up as a second-level, for some individuals.

The "WHY" is very simple, though:
Teflon causes the immune system to break down.
That's true for every single form of non-stick, including all the new versions, even those that are somewhat more safe ("oxidize less") ... and this keeps coming up, again and again, no matter the type of non-stick.

So it's worth repeating, and much more specifically this time:
Teflon causes the immune system to attack the thymus gland.
Please understand that I am not against technology at all... In fact, I'm constantly amazed at the research that is happening, and how new products are constantly being developed that are safer than they used to be.

It's just that I'm aware that "we don't have it... quite yet."

Although the modern-day enamel is a different technology than teflon, the net result is the same:
It causes damage to the immune system.
Back to Teflon, or rather, "Polytetrafluoroethylene":

"Polytetrafluoroethylene (PTFE) is a synthetic fluoropolymer of tetrafluoroethylene that has numerous applications."
"... consisting wholly of carbon and fluorine"
Now, it's the "fluorine" that's the problem.

Why is fluorine a problem? Kids need it for dental enamel, right? Yes, and... Wow, that's too big a question just right now...
(and no, I'm not mistaken here... there's a little more info about Fluorine and Fluoride closer to the end of these notes.)

I know there is a lot of debate about fluorine. (Okay, so I haven't had a chance to follow that one through, but there certainly is a dilemma. Maybe another person will ask about it one day, and we'll explore it, but somehow, "radiation" comes up as a possibility, although toothpaste is okay, assuming it isn't swallowed ... and see the excerpt about teflon that comes next...)

Just a tiny bit about teflon:
"In the 1990s, it was found that PTFE could be radiation cross-linked above its melting point in an oxygen-free environment. Electron beam processing is one example of radiation processing. Cross-linked PTFE has improved high-temperature mechanical properties and radiation stability. This was significant because, for many years, irradiation at ambient conditions has been used to break down PTFE for recycling. This radiation-induced chain scission allows it to be more easily reground and reused."
What you might like to understand from that, is that PTFE can cause radiation.
... and we know now that radiation damages genes.

There are additional pieces related to teflon, but that's enough for here.

By the way, since so many people these days ARE using non-stick cookware, I will mention the following, because if you are buying any, you'll at least want something to go by:
I have found only one or two variations of non-stick cookware that are anywhere near "safe", and those only for a "lifetime" of around 7 months for a pot or pan, before it needs to be replaced.

The most reliable products available at the moment are those made by Cuisinart... but even then, the lifespan should be treated as "disposable after 7 months or so", and you'll want to replace it sooner if you heat fat regularly, regardless of the temperature.
If you use Cuisinart products and follow these guidelines, you should be okay.

Next: The genes

Teflon and non-stick have come up again and again on chromosome 8. That was enough information leave most people with, as I always find there is more, and just giving an individual "information" sometimes allows the human system to figure out the correction it needs.

However, I decided to look up Chromosome 8, to see what came up. Please note that the following information is specific to just Peppermint, and others of her family, i.e., DNA-specific. (There is still something more "Generic" on chromosome 8, but we didn't make it to that today.)

So, the first word that stood out was "Lymphocyte". That's it. Think immune system again.

"A lymphocyte is one of the subtypes of white blood cell in a vertebrate's immune system. Lymphocytes include natural killer cells (NK cells) (which function in cell-mediated, cytotoxic innate immunity), T cells (for cell-mediated, cytotoxic adaptive immunity), and B cells (for humoral, antibody-driven adaptive immunity). They are the main type of cell found in lymph, which prompted the name 'lymphocyte'."
So if you look up Lymphocyte on chromosome 8 in the gene map database, you'll see that there are several records.

They are ALL very relevant. However, one of them more so than the others... but just to begin with: It's the RIGE gene:
Chromosome: 8
Genomic Start: 8:143,018,484
Cyto Location: 8q24.3
Gene/Locus: LY6E, RIGE, SCA2
Gene/Locus Name: Lymphocyte antigen 6 complex, locus E (retinoic acid induced gene E)
Gene/Locus MIM Number: 601384
This is helpful just for Peppermint to see, but now there is another thing I need to find... so I check for Lymphocyte entries on ANY chromosome. There are 43 results, but there's ONE that comes up as causing immune deficiency again and again, in almost everyone, when they use non-stick pans. (This is full of really stressful vibes... it feels like it's really highly relevant, and helpful to figure out a correction for.)

It's the LFA1A on Chromosome 16:
Chromosome: 16
Genomic Start: 16:30,472,661
Cyto Location: 16p11.2
Gene/Locus: ITGAL, CD11A, LFA1A
Gene/Locus Name:  Integrin, alpha-L (antigen CD11A (p180), lymphocyte function-associated antigen-1, alpha polypeptide)
Gene/Locus MIM Number: 153370
Here, it's very interesting, because it feels like I'm "re-inventing the wheel". Somehow, it feels like researchers already are aware of this, and may even have published it, but I can't find it in either OMIM or Ensembl, searching under variations of teflon, Polytetrafluoroethylene, PTFE, PFOA, and Perfluorooctanoic acid, all of which represent teflon. I do find information where it's related to medical uses, but that's an entirely different application and seems to work fine. It's cooking with it that causes gene issues and compromises of the immune system .

Back to Peppermint again: Peppermint and her family didn't have any pots that were comfortable for the human body. Changing cookware (to mostly the newer stainless steel pots with the 3-ply aluminum core bottom) is "an easy fix," and something that Peppermint plans to do.

Enough about pots for now... I'll probably be writing more another time, as it comes up fairly regularly.

So we move on, but we're still on the subject of food, and cooking.

Peppermint has always tended to eat lots of salads, but for her, there are issues with inflammation of the digestive tract. At least, that's what keeps on coming up for her.

As it turns out, there is another link here:
PFOA, or Perfluorooctanoic acid:  https://en.wikipedia.org/wiki/Perfluorooctanoic_acid  is often simultaneously present with non-stick products, and it actually has it's on "heading" on the Teflon (Polytetrafluoroethylene ) page in Wikipedia: https://en.wikipedia.org/wiki/Polytetrafluoroethylene#PFOA

There, it states very plainly that

"The studies concluded that there was probably an association between PFOA exposure and six health outcomes: kidney cancer, testicular cancer, ulcerative colitis, thyroid disease, hypercholesterolemia (high cholesterol), and pregnancy-induced hypertension."
While Peppermint doesn't actually have ulcerative colitis (yet), it was actually developing.

And, while ulcerative colitis could have many sources, and it does... for Peppermint, this is one of the pieces of her puzzle. (She also happens to have thyroid issues, which is listed here, but the non-stick cookware isn't directly part of that issue. More about that later, though, because there were several related things that all came up today.)

So we find that there's an IBD21 gene on Chromosome 18 that's very helpful for Peppermint, as it has been affected mostly during her time of using non-stick cookware (i.e., not inherited).

Before we look at the IBD21 gene, I would like to note something that is really helpful to understand: Genes are NOT there to cause disease.

A gene is a recipe for a protein. It's very simple.

SOMETIMES, the fact that we have a particular gene may be a problem, or sometimes, if we're missing a gene, that might be a problem ... and that depends on the gene, and all kinds of other things as well.

Alternately, the gene might be just fine, but it may not be switched on, or off, appropriately... or we might have a variation that can cause problems... or any other number of things.

Sometimes, there are "levels" of genes. In other words, there are combinations that are more likely to cause problems.

So the fact that there is an IBD21 gene, doesn't matter, if it's correct. It's only when there is something else added to the mix, that it impacts the individual... in this case, Peppermint.

Chromosome: 18
Genomic Start: 18:0
Cyto Location: 18p11
Gene/Locus: IBD21
Gene/Locus Name: Inflammatory bowel disease 21
Gene/Locus MIM Number: 612354
... and in Peppermint, there's something going on here, but there's another place before this, that holds the key.

So, there's another gene coming up really close to that one, though, and there IS a significant family history for this one:
Chromosome: 18
Genomic Start: 18:670,011
Cyto Location: 18p11.32
Gene/Locus: ENOSF1, RTS
Gene/Locus Name: Enolase superfamily member 1
Gene/Locus MIM Number: 607427   
We didn't find the time to follow any additional links for either of these two genes, however, just the knowledge has allowed many "adjustments" to happen. The original ENOSF1 gene is doing much better, although the IBD21 gene hasn't picked up the new patterns yet (this info is updated July 17, 2017). The IBD21 gene, however, was just a "clue" along the way, to get to the ENOSF1 gene, which had a far greater impact on more digestive issues, for Peppermint.

For this time, we left it that there wasn't very much that Peppermint needed to do, except, maybe, to begin looking for a new set of cookware. (That's just a little thing, right?!!!)

As well, it was helpful for her to be aware that her digestion would do well with a few more cooked vegetables, rather than salad most of the time. However, just knowing about the genes that came up today was helpful, and means that her body will update another recipe or so.

There was "something else" we were aware of throughout the consultation, and it was somehow related to what we were working on today.

There was something about grade school, and something about "fluoride".

Maybe Fluoride was coming up because of the non-stick? That, after all, is "Polytetrafluoroethylene" ... which consists "wholly of carbon and fluorine".

Are Fluoride and Fluorine related? Yes, of course they are.
"Fluoride ... is an inorganic, monatomic anion of fluorine with the chemical formula F-. Fluoride is the simplest anion of fluorine."
So Peppermint talked about her childhood experience at school, beginning to use fluoride, and fluoride toothpaste ... and then, she mentioned "chewing on some pill-things that turned everything red where you had missed brushing."

Oh my... THAT was a REALLY big reaction! I KNOW there's something important when I can "feel" it like this.

I knew immediately that THIS was where Peppermint's enlarged thyroid gland had started... back in grade school. Wow!

The same ones that Peppermint used then, are still sold as Butler G-U-M Red-cote Dental Disclosing Tablets. I would prefer not to mention brand here, but it's very important. It feels like there are others who were in Peppermint's class who also have thryoid issues that began there.

I'm now aware that this was a common practice then, and may still be... but now there are other brands available. I can't speak for all of them, but the others I'm aware of are okay.

It was "radioactive residue" that was coming up, and "radioactive" and the thyroid gland are linked.

It feels like that brand may still have radioactivity, although somewhat less now... but still enough to damage the thyroid, based on the individual's genes, amount of use, etc.

I looked at the ingredients, and can't find anything off, but somehow, the radioactivity is there. It seems that the "equipment" was responsible... so maybe the equipment had been used for something ELSE as well (or something in the plant?), which caused the problem with the dental tablets?

This is one of those situations where I CANNOT SAY ANYTHING FOR SURE. I don't exactly know WHY... but I'm guessing that they would find a connection between the use of those tablets, and people's thyroid issues (a percentage of them... maybe about 2 in 100 or so, but that's fairly significant).

Peppermint's thyroid is beginning to have peace.

(published 07/17/2017)
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   02/15/2017  ~  We only made it as far as the word ''enzyme'' for today.
 
 

02/15/2017

We only made it as far as the word "enzyme" for today.
Consultation for Dolf, a 48-year old male

This was an in-person, first-time appointment.

There were lots of different things that came up, so we explored some of them, and I'll share only a few of them here, because during the first few appointments, we often focus more on the "broad strokes", rather than getting down to more core things... such as DNA.

However, I'm including some of this here because it's rather a fun illustration of someone's "DNA recipe book" being completely unique.

As we talked about DNA, and the basics of our DNA cookbooks, I was explaining how we tend to "make substitutions" when some of the core ingredients are missing.

With Dolf (just as it happens with most others), the story told itself... but please understand that this is in "symbols", and it's kind of like giving an analogy. It works, though.

We always begin by choosing a present-day recipe, but the DNA says something like "Given what the instructions are, here's what I'm making..."

Our "recipe du jour" was ice cream, because Dolf happens to enjoy life, and so sweet things come easily into his food.

So what came was that sugar peas were more handy than milk, and he could make nice "ice cream" using sugar peas as the basic recipe!

You might understand that this is the DNA asking about protein...  So, imagine the DNA saying "Protein...??? Did you give us some of that? Do you mean to say there should be enough for having something nice? Alright, so the veggie version of ice cream will do just fine, thanks."

In this case, it means that Dolf's DNA maybe doesn't always get just the right version of protein. Anyway, his ingredients overall, are nice, and lots of them are "sweet". But it does come up as "need more food..." (Dolf is tall, and really on the "slender" side... )

In this case, I wasn't too surprised at how the story told itself, because Dolf had already indicated that he was mostly vegetarian, and eats mostly organic food.

We don't usually have a chance to begin working with genes during the first consultation, but it's somewhat easier with an in-person consultation, and so we did today.

Dolf has high blood pressure, and it is familial. Other members of his family also have high blood pressure. It came up as related to cholesterol processing, and in his case, he seems to be missing a very core gene.

"Missing" a gene is lingo for a gene that is not functioning correctly, in a big way. It may have most of the nucleobases, but if one of them got changed to something different, or went missing, or something like that, then the gene may no longer make the protein, and it could be referred to as a "missing gene."

So today, we took the time to look at one of the genes that was coming up, related to cholesterol.

The HCHOLA3  gene came up initially, but there are currently 27 entries for cholesterol in the gene map database, and there are many others that apply as well. Some of them seem to interplay with each other.

Today, we just wanted "an in"... a way to begin seeing what is in Dolf's physical, so the HCHOLA3 gene will do just fine.

Chromosome: 1
Genomic Start: 1:55,039,475
Cyto Location: 1p32.3
Gene/Locus: PCSK9, NARC1, HCHOLA3, FH3, LDLCQ1
Gene/Locus Name: Proprotein convertase, subtilisin/kexin-type, 9
Gene/Locus MIM Number: 607786
Phenotype: Hypercholesterolemia, familial, 3;  {Low density lipoprotein cholesterol level QTL 1}  ; and  {Low density lipoprotein cholesterol level QTL 1}  
It's the "kexin" that's the key here: https://en.wikipedia.org/wiki/Kexin
"Kexin (EC 3.4.21.61) is a prohormone processing protease found in the budding yeast (S. cerevisiae). It catalyzes the cleavage of -Lys-Arg- and -Arg-Arg- bonds"
So what's coming up for Dolf is that something hinges on the "catalyzing the cleavage of -Arg-Arg- bonds"... and the Protease is also highly important. (The amino acids aren't connecting together particularly well just now... some of the amino acids are doing okay, while others aren't... and Arginine  [Arg] is one place to begin.)

"A protease (also called a peptidase or proteinase) is any enzyme that....
Enzymes... and hormones... and amino acids chains... are all made from protein. The body needs more than you might think. DNA is quite simply, instructions for making proteins.

So with Dolf, we only made it as far as the word "enzyme", as he doesn't make this one (Protease) very well... and there will be other enzymes too, since there are tens of thousands of enzymes in the human body, and they perform so many critical tasks.

But we'll work with this for now, as awareness is often one of the first pieces.

The question might be, "How can you integrate corrections to your recipe books, if the underlying proteins don't connect well?"

This is the case here... but you'll see (soon...): It only gets better!

(published 07/22/2017)
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   02/21/2017  ~  Is that water really H2O?
 
 

02/21/2017

Is that water really H2O?
Consultation for Dolf, a 48-year old male

Last time, we looked at a gene that might begin helping with Dolf's high blood pressure; that was the HCHOLA3 gene, and today, it feels like it's already sequencing correctly.

Please keep in mind here, though, that each and every cell in the body has a set of unique DNA... and so usually, when something begins sequencing correctly, it may only be in a single cell or so, initially. As time goes by, the new changes would self-propagate.

(Most everyone has heard that it takes about 7 years or so for every cell in your body to turn over. It's not completely correct, but it helps to understand that general idea.)

Today, we talked about water... that is, water that we take into the body.

Dolf has been using water from a water ionizer... one of those alkalizing water machines, which I haven't yet found one that feels helpful, let alone non-toxic... and this seems to be true for everyone.

I haven't ever tried explaining this before... it's always just come through SO CLEARLY (i.e., "this is really important!") that...
these machines are not only UN-helpful, but that they actually disrupt the body's own healing mechanisms.
I hadn't asked specifically what the physiology and chemistry was related to, but I did know that it had something to do with how the water is structured. As I begin getting the information, though, I can understand now that if I had tried to explain this earlier, it might have helped more individuals.

So here goes... Let's figure out why water from these water ionizers keeps coming up as "very incorrect".

First of all, water ionizers create alkaline water by splitting apart water molecules. This artificially create alkaline water, and isn't anything at all like alkaline water that nature provides.

So, somehow,
the ionized water "is structured well for bringing electricity through the body"
... and just WHY would you want that? Please think about it... Is that really what you would want to do?

Take the basic premise of alkalizing the body, and that's an entirely different question... and I'm sure you'll be hearing more about that along the way. Everyone is UNIQUE... and there is no "one size fits all" where your DNA is concerned.

So with this water, the way the overall picture goes is that often, the individual notices a change, and that seems like a great thing, and so he or she is happy about that.

Yet, in time (within a month or so), something else comes up... and after that, there's a never-ending sequence of "yet something else". Of course you never attribute the "something else" to the water, because you saw the positive results in the beginning, right?

The body, however, is simply creating a "do-my-best" scenario, for these never-ending situations that keep piling up... and sometimes the new "something else" is not even related to the last one.

Underneath it all, however, the body isn't actually doing any better.
The body tries to keep everything correct, but it's like being on a treadmill, and it can't actually make progress.
So for the individual, it may feel like initially, there's an improvement... yet, in the core structure, in the very protein molecules of many of the glands of the body, the DNA is making less and less reliable bonds connecting all of the proteins in a string, and the DNA may fragment.

So is that a technical term ("DNA may fragment")??? Why not...

Alright, so how about you use the technical term "DNA Oxidation" in it's place?

I can't actually send you a link to that page in Wikipedia, because it's "incomplete" and therefore not as accurate as I would like it to be... but the basic description (and that IS accurate), is:
"DNA oxidation is the process of oxidative damage on Deoxyribonucleic Acid. It occurs most readily at guanine residues due to the high oxidation potential of this base relative to cytosine, thymine, and adenine. It is widely believed to be linked to certain disease and cancers."
One of the types of oxidation damage used as an illustration is "highly really close..." to the version caused by water ionizers in the body. The description says:
"two of the most common damages change guanine to 8-hydroxyguanine or to 2,6-diamino-4-hydroxy-5-formamidopyrimidine"
Sounds nice, right?

So for anyone who doesn't yet know much about DNA, here's just a little bit of background info to help you understand this better:

There are 4 basic building blocks of DNA... the 4 nucleobases (https://en.wikipedia.org/wiki/Nucleobase):
"There are five primary, or canonical, nucleobases: adenine (A), cytosine (C), guanine (G), thymine (T), and uracil (U); they function as fundamental units of the genetic code."
And in the double-helix DNA, wherever there's a G one side, there's almost always (or rather, there is intended to be) a C on the other side... and vice versa... and if there's an A on one side, there's almost always a T on the other side... and vice versa.

There another source that illustrates what happens quite nicely. It's the textbook Genetics: From Genes to Genomes, 5th edition, by McGraw-Hill Education, published in 2015 (http://amzn.to/2uadPz5).

So here's the basic idea:
Oxidative damage is with the nucleobase G, or the Guanine, which you know is supposed to pair with C, or Cytosine.
The damage changes Guanine to a form that would be labeled "GO"... Guanine with Oxygen.

When the DNA replicates (as it must do every time a single cell divides), there are two NEW resulting strands, as is almost always the case.

ONE of these strands may look like the original one, with the G in the same place, which may or may not pair next time with the C...

(The information that I get is that this could well be a "may not" [pair correctly next time] because the oxidation continues, and that G may also become a GO. In that case, there's no longer a master cell with the correct copy... )

The GO (Guanine with Oxygen) on OTHER strand CANNOT match up with a Cytosine, so the A, or Adenine,  slips into that space, and from there on in (if not corrected the first time), forever after, when that molecule replicates (as you know it will), the A will match with a T.

Now, rather than a G-C pair, you have an A-T pair... at least half of the time (assuming the first strand keeps going with the G, without further mutations).
In other words, you've just changed a lot of recipes in your DNA cookbook... and please understand that this particular version of oxidation is something that has been almost impossible to undo at the level of the DNA... partly because there is also another mutation that seems to be happening around the same time (also oxidation, but with a different base), and between the two of them, somehow, you've just undone your body's "proofreading genes", at least that's the way it goes in some individuals. Anyway, the net result is that so far, we're not managing to self-correct the DNA mutations from water ionizers.

So to continue: Not only have you just changed a lot of recipes in your DNA cookbook, but this seems to be happening on several chromosomes, and in several places, so it's not just one little random gene mutating. You're changing your entire bases.

You might ask, and just WHY does it matter if you now have an A and a T instead of a G and a C???

Because
DNA reads off codes that say "Put together this amino acid with this next amino acid... "

And each 3-letter code means very specifically, "THIS amino acid please"...
... and the proteins that your body puts together make sense if they're put together using the amino acids that the recipe calls for, but if you try using a Tyrosine (3-letter DNA codon TAT) instead of a Proline (3-letter DNA codon CCC), your recipe might not turn out. Period.

It's not a (softer) "I can't make this protein quite correctly... but let's figure this out, and see what we can do with it"...

Rather, its' more simply, "I can't make this protein."

Given that proteins are what runs your body, this isn't a position you want to end up in.
The biggest thing with this is that the longer someone uses the ionized water, the more pressure there is in the cells, and oxygen keeps going higher, and lighter, and the DNA WILL keep on substituting A's for the G with Oxygen. It's not a one-time thing, it's ongoing.

Just in case you're curious, before I began delving into the actual chemistry and DNA of water ionizers, what I kept getting was something about "pressure" and "a highly incorrect version of water not leaving the cells", so bloat... liquid. Not edema, though, because edema is interstitial (between the cells), and this is inside of the cell membrane.

(Please note, that in many individuals who are on this system for a longer time, there may actually be audible "gurgles" in places where there shouldn't be any noise!)

It seems to get worse than that, though, because the "bloat" is inside the structure, i.e., inside the very nucleus of the cell, which is why the DNA damage is a severe consequence, and the degree of consequences seem to be magnified by the amount of time you're using ionized water.

In the beginning, the cell nucleus understands, because it's just a bit. It's not big-time through everywhere yet.

The body tries to keep up, and the DNA begins changing to include the mutations (mentioned above), and it's sequencing things that are still understandable. That's perhaps because a few mutations can be corrected... your DNA is a super-hero when it comes to "proofreading", but eventually it can't proofread well either, because that DNA has been impacted.

Somehow, the water isn't actually "water", because  the ions are "charged", but not working. Somehow it comes up as "splitting chemicals" too. ONE of the factors is that the ionized water isn't a very nice team player, as it isn't a cooperative member of the body's chemistry, and it makes everything move faster.

The question that came up as I was making my notes, was: "Can you make an atom from chemistry that's moving faster than the body needs?" ... but the answer that comes is that everything gets hooked on "running", but it's not particularly steady... and if someone then stops using the ionized water and the body needs to break the rhythm, then everything collapses.

In other words, the moment you stop, the body can't begin to fix all the wrong valences (and I'm NOT talking about window treatments... that's valance spelled with an "A"!).

Valence actually comes up more often than you  might expect, so here's a definition:

"In chemistry, the valence or valency of an element is a measure of its combining power with other atoms when it forms chemical compounds or molecules."
The picture I've been getting is that there are farther consequences, and another (DNA) mutation that easily happens as well (which I've already also mentioned), but I've written quite enough here. If it's important, i.e., if "more" keeps coming, and it seems to be important and impacting others significantly, then I'm sure you'll be hearing more about all of this.

In some people, the damage is easily undone, however, in others, it may take years of trying, and in the meantime, the individual's various health issues begin to manifest. Some people may be much more impacted than others, but this all comes through so very clearly and the only information I've EVER gotten is to avoid alkalized water. (I mean, that while everyone is unique, and for one person, one thing might be correct, and for someone else, it could well be the very opposite, but with this situation, there are no exceptions... at least, that's what I get.)

By the way, while this more or less happens the fastest (or worst) in the chemistry of people who use alkaline water from water ionizers, "alkalizing" overall, also brings this equation, although possibly on a much smaller scale.

Alkalizing changes the oxygen to make it likely to oxidize (as with the Guanine-Oxygen combo above), which then pairs with the Adenine rather than the Cytosine, and in time, more changes.

One more thing I need to explain here: Somehow, I'm aware of something in a new way, even though I don't necessarily have the complete understanding. As I learn more and more (and not just from the books, but from all of these very real-life scenarios), I understand more, and sometimes I will end up going back and qualifying previous things. Also, sometimes, I try to understand something logically, and it doesn't always make sense.

However, I somehow know how to see things that are happening, perhaps looking at a different place than where researchers know where to see, just yet...? In the meantime, we know that the understanding of genetics, and everything impacted by that, is growing in leaps and bounds, and somehow, I am aware of the deeper "inside information". (411???) E.g., researchers aren't looking at the lagging DNA strand as much as at the leading DNA strand... but they ARE looking at the messenger RNA, and that's getting there.  

So, my understanding is that "The proof is in the pudding." In other words, "Was the recipe correct? i.e., Did the pudding turn out nicely? ... and if so, WHAT was the recipe that you ended up using?"

... and somehow,  those are the answers that I provide, and it's in that equation, that the physical learns to make "corrections" and begin "updating the recipes".

So to put this into perspective, somehow, the mutations that are happening, happen on the lagging strand of DNA, and just one or two on the leading strand. I'm not even positive that this science works, but somehow, the lagging strand gets a lot of "leeway" and that's all I need to know. From there, I can help the body to begin correcting the pieces it needs.

So back to Dolf...

Needless to say, I recommended that he stop using the ionized water.
(Please note here, that for some people, they will need to adjust gradually, and continue using the water on a less and less alkaline setting, until it's just purified water.)

Aquafina water blows the body back to a more normal proportion so that the valence can begin to quiet (slow) down a bit.

So I recommended that he begin drinking Aquafina water for a whole week, and then he could simply use the filtered water that he already had previously.

Moving on:
Next, we went back to looking up Kexin, which had come up in his previous consultation, related to blood pressure. Last time, we had looked at the HCHOLA3 gene: https://www.omim.org/search/?index=geneMap&start=1&limit=10&search=HCHOLA3

Today, we looked up Kexin in Ensembl, which is "a genome browser for vertebrate genomes that supports research in comparative genomics, evolution, sequence variation and transcriptional regulation."

There, we found the following helpful gene: PCSK4, which is labeled as "Proprotein convertase subtilisin/kexin type 4". It's the "Kexin type 4" that's relevant.
Gene/Locus: PCSK4    
Description: [Proprotein convertase subtilisin]/kexin type 4
Chromosome: 19
Genomic Start:  19:1,481,427
Cyto Location: 19p13.3
Gene/Locus MIM Number: 600487

Many entries for variants of this gene are listed.

Of those listed, I already know that at least one of them is relevant. The first on that comes up is: (it's currently record #62, but that is likely to change):
Variant ID: rs780301806

Type: Frameshift variant
A frameshift is "a sequence variant which causes a disruption of the translated reading frame, because the number of nucleotides inserted or deleted is not a multiple of 3"... and thus, frameshifts result in a completely different translation of the genetic code from the original.
This frameshift is the result of the deletion of a base... Guanine, in this situation.
This variant is given as "ancestral", so it's often inherited, as it would have been in Dolf's case... as is the elevated blood pressure, which is highly relevant.

So obviously, here is a problem, because when the "reading frame" of the gene shifts, it results in a mis-reading of the genetic code.

Everything from that point on, for a long stretch of his chromosome, didn't work...

At some point, although he wasn't (yet) able to match the correct codes (because there are other underlying factors), he is able to add ANOTHER frameshift mutation, this time ADDING a base. (It's the frameshift mutation listed currently at record # 194, although that is apt to change... but the Variant ID is rs759114312.)

So since the update, that gene is more or less okay, although there are still more things relevant to the blood pressure.

The PCSK4 gene is supposed to make Kexin type 4 (simply a prohormone that processes protease), but some other variation had been there instead.

Next, we looked at the renin-angiotensin system, since that is also highly relevant to blood pressure.

"The renin–angiotensin system (RAS) or the renin–angiotensin–aldosterone system (RAAS) is a hormone system that is involved in the regulation of the plasma sodium concentration and arterial blood pressure."
On this page, the main thing that stood out was (in the first few paragraphs):
"Aldosterone causes the tubular epithelial cells of the kidneys to increase the reabsorption of sodium ions from the tubular fluid back into the blood, while at the same time causing them to excrete potassium ions into the tubular fluid... "
So it's the Potassium Ions that are part of Dolf's puzzle.

What came up is that he needs to excrete more potassium (but the body wasn't allowing that previously).

So we looked up Potassium (and not Aldosterone, because it was the potassium that is the "next piece"): https://en.wikipedia.org/wiki/Potassium
"Potassium is a chemical element with symbol K (derived from Neo-Latin, kalium) and atomic number 19."
What comes up on this page is very specific just to Dolf, and it's about the properties of Potassium.

So on the sidebar at the right, there are several different headings. One of them is "Atomic Properties", and under that, there's a sub-heading entitled "Ionization energies".

There, one of the lines says, simply,
"2nd: 3052 kJ/mol"
That's all he needed for now. Just becoming aware of this information allowed something to begin happening.

Please understand that this was only Dolf's 2nd appointment, and the body still needs time to begin making changes. It must begin with small changes, and in a gradual way... you can't just begin making big updates, because each and every thing affects many other things.

So the chemistry is adjusting, and we'll eventually be able to begin working with other things as many of the underlying layers begin updating.

... now, one more piece:

In talking about food, somehow, Dolf had told me that in amongst his careful, mostly organic diet, he did occasionally find himself reaching for potato chips. He told it to me with a bit of a sense of humor, indicating that he had childhood memories of eating potato chips and that he sometimes gets carried away when eating them. Therefore, he has been trying to eat them less often.

Rather than just grin and accept the humor, what actually came up was "Hold on... not so fast!!! There's a REASON you can't stop eating them!!! You NEED them."

And so we looked up potatoes...

I'm not sure anymore just exactly WHERE I found the link or the information that we needed, but the long and the short of it is that "Potatoes have "4-O-caffeoylquinic acid (crypto-chlorogenic acid)", which is a quasi-essential nutrient for Dolf. (Probably related to his genes, somehow!)  

So we looked up the lovely long word, 4-O-caffeoylquinic acid, which took us, simply, to Caffeoylquinic acid: https://en.wikipedia.org/wiki/Caffeoylquinic_acid

There isn't much info there, but the last sentence says very clearly,
"Multiple groups of caffeoyl can be bound to quinic acid. There is a positive correlation between the number of caffeoyl groups bound to quinic acid and the rate of ATP production."
ATP production! That's a pretty core function in our physical bodies, and somehow, Dolf is "lagging" a bit with energy.

Hmmm... is this possibly another piece that's causing the kJ/mol equation related to the potassium? ("kJ/mol" is KiloJoules per mol, and Energy is measured in joules). It appears to be so.

It appears that the potato chips keep Dolf's immune system moving.

So a quick link to Chlorogenic acid: https://en.wikipedia.org/wiki/Chlorogenic_acid

Wikipedia describes chlorogenic acid as
"the ester of caffeic acid and (-)-quinic acid"...
and Dolf is needing both of these.

There is apparently a gene for this substance which is missing in Dolf.

We didn't have time to go explore that gene today, but from what I can tell, he hasn't ever had it, and many others don't use it when they do have it, but for Dolf, the potato chips are very grounding, as they behave somewhat like the gene would.

By the way, the caffeoylquinic acid is found mostly in the potato skins, thus, the potato chips, because the skin is there (... and they are enjoyable as well)!

You might like to notice, as well, that on the Chlorogenic acid page, under the heading "Research", it says
"Taken as a dietary supplement or in coffee, chlorogenic acid has been shown in review articles to have a small reduction in blood pressure..."
... so it appears that Dolf has been doing some form of "self-medicating" (rather unintentionally!).

(published 08/04/2017)
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   05/14/2017  ~  Hey, gene, where are you?
 
 

05/14/2017

Hey, gene, where are you?
Consultation for SunnyHeather, a 54-year old female

SunnyHeather has recently been having symptoms of numbness in her finger tips, and has also been waking up at night or in the morning with  a feeling like her entire arm has "gone to sleep", and it takes a few minutes for the circulation to come back into her hands at these times. She has also recently been lifting and carrying many large boxes.

I was initially given that there is permanent nerve damage present, but that has since changed.

We begin to look at the situation, by looking at the chromosomes. The first chromosome that comes up as the main one with the issues, is chromosome 9.

Chromosome 9 also happens to come up for SunnyHeather as the "main one with issues"  for her, so it's not surprising that we need to begin there. I am also aware that there is also something helpful today on chromosome 1, but we'll get to that later.

At this point, with just beginning to delve into this issue, there seem to be 2 major places (DNA) involved. (Once we get to those, we will probably be able to access the "next layers".)

About that "main chromosome with issues": What I have found, is that everyone has one or two chromosomes that have many issues on them... more so than the rest of their chromosomes, and sometimes, when something goes awry on ANY gene, the entire sequence is off, and sometimes the genes that are "off" are key players in managing DNA, replication, amino acids (which are really basic building blocks that are the "ingredients" in the recipes that the DNA makes...), chemistry, or something else that can throw an entire organism into a bit of a quandary...

... and in this case, it's the "amino acids" component that is coming up, because there are many that are not being well formed here, but the correction of the genes that we'll be looking at in a few minutes, will put that basic piece into place. (Of course, there are many more components that could give us a few different ways to approach this whole thing, but we're going to start by looking at one single gene.

So I scanned through some of the genes on chromosome 9, and the gene that I ended up needing to find a correction for first, was the HPTP gene: https://www.omim.org/search/?index=geneMap&start=1&limit=10&search=HPTP
Gene/Locus: PTPRD, PTPD, HPTP
Gene/Locus Name: Protein tyrosine phosphatase, receptor type, delta polypeptide
Chromosome: 9
Genomic Start: 9:8,314,245
Cyto Location: 9p24-p23
It was the “Protein tyrosine phosphatase” that was really helpful here, as something was coming up as "damaged".

Next, we looked up “Protein tyrosine phosphatase”: https://en.wikipedia.org/wiki/Protein_tyrosine_phosphatase

And in looking at this, the puzzle piece begins to make sense: There's a significant area of the entire chromosome that is causing a very basic structure to "not function" ("not function at all", as opposed to "not function decently")...

Let's go back to the gene map database: When I search, there are 48 different entries that come up for “Protein tyrosine phosphatase”: https://www.omim.org/search/?index=geneMap&start=1&search=%22Protein+tyrosine+phosphatase%22&limit=10

3 of these genes are on chromosome 9, and 2 of them both on the short arm (P arm, P for "petite") of this chromosome.
(See https://en.wikipedia.org/wiki/Chromosome_regions for the naming of the various parts of a chromosome.)
... but it's the first of these genes that is helpful to look at. As it turns out, in SunnyHeather, this entire gene is "missing".
Is that possible? A "deleted gene"?

Apparently, if a base pair (like one of the nucleobases) isn't there, the whole area becomes in-operable, and the DNA sequence doesn't make any sense until it reaches a different area of the chromosome where it may begin reading the non-mutated genes... and if that has happened, then a gene is said to have been "deleted". Other genes may also be impacted, as is the case here, and as we've also seen in another individual... sometimes an entire area gets "deleted", and that's the case.

... and there are actually genes delegated to try to reverse this, but they can get mutated, and then everything in that area is impacted. Every single chromosome except 21 and 22 has one or more genes labeled as "chromosome [location] deletion syndrome", or they may have comments including "contiguous gene deletion syndrome" and some have many of them. Please keep in mind (again!) that genes are not there to cause disease... but rather, they are labeled and named sometimes according to the "results" when something isn't working well (which is often related to underlying things and stresses, and the "switches" on genes).

As I searched on genes related to "deletion syndrome" (https://www.omim.org/search/?index=geneMap&search=%22deletion+syndrome%22&start=1&limit=100), I did notice a gene that, in SunnyHeather, has been switched on and off regularly, since her childhood, and here, I'm aware of another piece that's somehow related to the gene we're looking at.

This next piece may seem like a it's a completely off-subject topic, however, it's one of the HUGE reasons this deletion is happening...

It's related to a "model of discipline" that was not only not kind for a young child, but which was "unpredictable", and which resulted in withdrawal and trying to please often...   and it's the "too many days of crying" and often crying deeply within, that sets this gene of and on again and again.

Please note, it used to be the "norm" for discipline in some cultures, and the genes carry the impact of similar things from the ancestors, so people have to learn to "unlearn" the very behaviors that very often begin in the childhoods of others before them.

What I understand (not how SunnyHeather herself describes this, but what "is there") is that she would often only be looking to connect, and not doing anything "wrong", but rather than being hugged and held, the result was not only rejection again and again, but also very harsh discipline along with it. That's what was coming. (What I get is that this was from age 1½ or 2 years old, and onwards. So small, and I feel the sadness underneath...)

SunnyHeather easily verified the "discipline", and also the very unpredictable nature of it, and interestingly enough, she can't remember what she might have done that often to cause the response. "Unprovoked" would probably be the correct term. She does remember it being traumatic, though, and later, just called her mom "strict".

In any case, the physical was impacted in that SunnyHeather's body released too many hormones associated with tears (as in sobbing or crying)... and please note that the physical (the soft, sweet child) still needed to be held often, and it's more the lack of being held than the actual physical discipline that results in this syndrome. This information is coming as I'm adding my notes, and so, I need to add here, that's it's not uncommon (that the deletion of genes is present, related to extreme stress, or discipline, or even just unavailability of the parent).

The lesson here, especially for parents and grandparents, is to hug your children and other family members often and easily... and be sincere... let the child FEEL the caring that you have for her or him... it's much simpler these days, but being cognizant of the impact that ANY beautiful sharing and caring brings, will also bring healing for others... and it's not too late to "make up for lost time", not just for children, but for grown siblings, and everyone else as well:
Caring touch can correct genes.
So, the gene that I am aware of in SunnyHeather that had been switched on and off regularly since her childhood, was the DEL9p24.3 gene on Chromosome 9, but as usual, in recognizing something, it can begin to correct itself, along with the many happier hugs and connections that SunnyHeather has received along her life's journey... siblings included.

Now, back to the "missing" gene:

I had already known about this particular base pair deletion, as I had "found it" earlier in the morning, when I was fixing breakfast, and it's the reason that we began today, checking for something significant on chromosome 9. (Sometimes I'm already tuning in to find the information I need, well before the actual physical interactions with the information.)

Now, all I had needed to do was find the part of the chromosome that was affected... and find the REASON it was such a big deal.

In looking up the function of this location on the chromosome, we can find the next piece, so back to Wikipedia:
“Protein tyrosine phosphatases are a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins ... These enzymes are key regulatory components in signal transduction pathways (such as the MAP kinase pathway)”
... and a little bit farther on in the first paragraph, the highly relevant piece is:
“Together with tyrosine kinases, PTPs regulate the phosphorylation state of many important signalling molecules”
Let's look up phosphorylation for a moment first, so that there's a better understanding of the health issues here: https://en.wikipedia.org/wiki/Phosphorylation

The basic description describes that:
Phosphorylation allows coupling and addition of a phosphoryl group.
Yes, but what does that mean? So the following information is more helpful...
"A large fraction of proteins (between 1/3 - 2/3 of the proteome in eukaryotes) are temporarily phosphorylated, as are many sugars, lipids, and other molecules. Phosphorylation is especially important for protein function as this modification activates (or deactivates) almost half of the enzymes, thereby regulating their function."
Okay, so read that as "necessary for regulating enzymes"...  and enzymes underlie so many different things in the human body, and without enzymes, there are few chemical reactions.
(A quick primer:  https://en.wikipedia.org/wiki/Enzyme...  "Enzymes accelerate chemical reactions.")

For SunnyHeather, we're talking here about approximately half of her enzymes... and as I add that information, I'm realizing that that's exactly the same as the Phosphorylation page in Wikipedia indicated. This is quite significant. No wonder that SunnyHeather hasn't had enzymes to digest food well, most of her life! I wonder what else hasn't been happening in her body...!

... and just for clarification, yes, she is making those enzymes... but they are not a "heavy-duty variety"... (... and who wants wimpy  enzymes?!)

By the way, sugars were coming up as well, and I know that we'll be talking a lot about sugars and chemistry at some point, so I'll leave that for another time.

Going back to the Protein tyrosine phosphatase, we now follow the link for the “MAP kinase family”: https://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase
"A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine, threonine, and tyrosine (i.e., a serine/threonine-specific protein kinase)."
... and also:
"They regulate cell functions including proliferation, gene expression, differentiation, mitosis, cell survival, and apoptosis."
Both of those descriptions are important, and for today, we'll just follow one of the threads from here, but please note that "gene expression" (in the second note) is coming up and needs a bit of attention as well.

So it's the serine/threonine-specific protein kinase that's important here: https://en.wikipedia.org/wiki/Serine/threonine-specific_protein_kinase.
"A serine/threonine protein kinase (EC 2.7.11.1) is a kinase enzyme that phosphorylates the OH group of serine or threonine (which have similar sidechains). At least 125 of the 500+ human protein kinases are serine/threonine kinases (STK)."
Also, within the first paragraph:
“These enzymes transfer phosphates to the oxygen atom of a serine or threonine sidechain in proteins. This process is called phosphorylation.”
... and...
"Thus, the two substrates of this enzyme are ATP and a protein, whereas its two products are ADP and phosphoprotein."
Here, it's the ATP that is is very important, and it’s come up many times for others before. So we'll look up ATP: https://en.wikipedia.org/wiki/Adenosine_triphosphate
"Adenosine triphosphate (ATP) is a nucleotide (also called a nucleoside triphosphate) and is a small molecule used in cells as a coenzyme."

“It is often referred to as the "molecular unit of currency" of intracellular energy transfer.”
It is also known as “the powerhouse of the cell”, in more layman’s terms, and it's a really important concept to "get". It is more basic than almost any other thing:
"Do your cells have enough energy?"
And to elaborate just a little bit more, on that basic concept:
“Most cellular functions need energy in order to be carried out: synthesis of proteins, synthesis of membranes, movement of the cell, cellular division, transport of various solutes etc. The ATP is the molecule that carries energy to the place where the energy is needed.”
Did you get that? "The ATP is the molecule that carries energy to the place where the energy is needed.
... but the relevant piece here today is:
“It is one of the end products of photophosphorylation, aerobic respiration, and fermentation, and is used by enzymes and structural proteins in many cellular processes, including biosynthetic reactions, motility, and cell division.”
So, if something related to phosphorylation is gone, then the powerhouse of the cell is significantly reduced, meaning, there could be a lot less ATP than there ought to be... and for SunnyHeather, the protein tyrosine phosphatase isn't present correctly, and the net result is that at the moment, SunnyHeather doesn't have enough ATP. Basic currency.

Also, the "aerobic respiration" (mentioned above) has been a bit under-used for some time, although SunnyHeather had believed that her amount of exercise was sufficient... but a good workout every now and then would have been helpful!

So now we go back to Wikipedia, and the Protein tyrosine phosphatase page. The next link I followed there would probably have been under the heading "Classification" —> "Common elements", and it would have been one of the Pfam Clan links, but I don't find it just now. In any case, it took us to the following page: http://pfam.xfam.org/structure/4ERC

On that page, which is titled "Structure: 4ERC", one of the first lines reads: "Structure of vhz bound to metavanadate"

Bingo... VHZ. But, what in the world is that?

Not only that, but on the 4ERC page, there is a nice diagram showing the shape of the "Structure of VHZ bound to metavanadate", and in SunnyHeather, at that time, it was way far off. No match at all. (I'm writing up these notes in early August, 2017 , and it's much more connected... not quite there, but at least it's beginning to match.)

So next, we look up VHZ in Wikipedia. There isn't actually a page for it, but Wikipedia kindly provides the next piece: The search returns an entry (possibility), "DUSP23 ... protein-tyrosine phosphatase revealed by a novel 16-kDa VH1-like phosphatase, VHZ"... and that's much closer to the solution we’re trying to find.

So let's go to the DUSP23 page: https://en.wikipedia.org/wiki/DUSP23

Great definition! (???)  About as basic as you can get:
"Dual specificity protein phosphatase 23, also known as low molecular mass dual specificity phosphatase 3 (LDP-3), is an enzyme ...  that in humans is encoded by the DUSP23 gene."
Just what you wanted to know, right? (Is that in "English" or in "Chemistry"?)

However, it's sufficient. Remember I said that there would be another piece of the puzzle on chromosome 1? Well guess where the DUSP23 gene is? It's on Chromosome 1. Hmmm..... Interesting...

By the way, there WAS a listing for a "Dual-specificity phosphatase" on the Protein tyrosine phosphatase page, but it was labeled as "catalytic domain ... Structure of the dual-specificity protein phosphatase VHR"... so VHR, and not VHZ, which is why I didn't focus on that one, and had to find a round-about way (via an unknown link which was coming up as "the NEXT REALLY IMPORTANT THING") on the tyrosine phosphatase page, because it was the DUSP23 gene we needed to get to.

So, since the gene map database doesn't actually have an entry (yet) for this gene, we'll look it up in ensembl instead:
Gene: DUSP23
Description: dual specificity phosphatase 23
Location: Chromosome 1: 159,780,932-159,782,543 forward strand.
... and even closer now:

I need to find a better match, so we go to the gene map database and try to find the exact location of what we need. The best match we can find for now is something near the “DARC” gene, where the entry reads as “[Blood group, Duffy system]”

Gene/Locus: ACKR1, DARC, FY, GPD, WBCQ1    
Gene/Locus Name: Atypical chemokine receptor 1 (Duffy antigen receptor for chemokines)
Chromosome: 1
Genomic Start: 1:159,204,012
Cyto Location: 1q23.2
Gene/Locus MIM Number:
Description (Phenotype):  [Blood group, Duffy system] , and also [White blood cell count QTL]
I am trying to find the exact DNA “recipe”, i.e., the nucleobase sequence, just where the problem has been...


From there, I can figure out exactly where the issue is, and what it needs.

So now, the DARC gene is much nicer already, but the other gene listed here, the WBCQ1 gene, is off, but at least it's listed now.

That's the gene regulating "[White blood cell count QTL]", and that's been a problem for SunnyHeather ever since she was young as well. (Leukemia has come up for her before, and a more recent consultation found the gene related to that... but here is a part of that history as well.)

Everything has multiple avenues to get to the issue, and many things are often found as a result of several pieces, and even when a "gene" is off, it usually takes multiple pieces for that gene to cause the issues that people associate with a particular gene.)

So today, as I look at the graph, I don't even need to look at the specific nucleobases to sort it out. The soft lavender part of the graph shows the correct version, which will now self-correct in SunnyHeather.

The info, however, is that from somewhere around this gene (the DARC gene) and on, everything is way off... the code is shifted in such a way that it scrambles other things, and it’s there where the mutation is happening.

The DARC gene near the location 1:159,204,012, but things get worse from that point on, and by the time we get to the CRP gene at location 1:159,712,288, it’s not functioning at all. DNA must have codes that sequence the protein it must create, and when it's wrong, the body says "no way!" ... and that was the case here.

Back to the DARC gene location on the graph... We adjust a few settings, so that we can zoom to see the letters:

I notice that there is a CAC (Cytosine, Adenine, Cytosine) sequence repeatedly... and for each Cytosine that follows the Adenine, in SunnyHeather, it’s beyond recognition...

In looking at an DNA codon table, you’ll see that CAC calls for the amino acid Histidine, but SunnyHeather is not able to connect the histidine at all, and substitutes codes for Glutamine, Asparagine, and  Lysine instead.
Do you think she was making the correct protein?????
Happily, being able to see this piece, she can rearrange everything else.

“Histidine is an essential amino acid required for growth and tissue repair, blood cell production, and creation of the neurotransmitter histamine.”
As a child, even, SunnyHeather didn't get sufficient histidine...

The nerves in her fingers are doing much better now, today, after seeing the list of foods for hisitidine. That list would be:
Beef, lamb, cheese, pork, chicken, turkey, soy, fish, nuts, seeds, eggs, beans, and whole grains.
Her body wanted some choices and wasn't able to digest the vitamins from the mostly-vegetarian diet that she grew up on, so histidine wasn't used, even if present. Meat-sources would have fixed this issue.

Enough for this time...

(published 08/10/2017)
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   06/06/2017  ~  Angiotensin… and creative ingenuity
 
 

06/06/2017

Angiotensin… and creative ingenuity
Consultation for Stargal, a 63-year old female

Stargal commented that she has been having a strange sensation in her legs.

She described it as "restless", and she said as well that there was something like a soreness or achiness feeling along with that.
This had been adding to some difficulty she's been having with sleep.

As soon as Stargal mentioned the leg sensations, there was something that came through as "yes"... there are genes involved.

I am tuned in enough to know that Stargal's grandmother (on her mother's side) had something akin to restless leg syndrome... and she (the grandmother) actually has one of the genes mutated, enough to cause the syndrome.

Stargal herself, hasn't, until recently, had any issues with restless legs, but it's helpful to be aware that there are genes involved. Often, just being aware of that is enough to help the body to understand a "piece of the puzzle" that it needs.

Currently, there are 8 different entries that come up in the gene map database for "restless leg...", but it's the one on Chromosome 12 that is most helpful just right now: https://www.omim.org/search/?index=geneMap&start=1&limit=10&search=RLS1
Chromosome: 12
Genomic Start: 12:37,800,000
Cyto Location: 12q12-q21
Gene/Locus:  RLS1
Gene/Locus Name: Restless legs syndrome, susceptibility to, 1

Wow! There are a lot of "alleles" for this one, and Stargal knows just what she needs for today... and some of her symptoms shift now. However, there is a lot of information about "variations", and we may need to check back another time...

We had other things to focus on today, so we moved on:

We talked about diet, and various things that she's been trying to incorporate, but it's not quite there yet.  However, salt was one of the things we had mentioned (not just any salt, but the Hain Iodized Sea Salt), so we needed to look at sat in a bit more detail today.

Stargal has been using the Hain's iodized sea salt just a bit so far, but it's insufficient to make a difference so far.

We looked at the diagram of sodium chloride, which is different than iodized sea salt, but we needed to see what is there as well: https://en.wikipedia.org/wiki/Sodium_chloride

For Stargal at least, the diagram on that page is completely incorrect, and it brings "stress". This version of salt, for her and other family members, "denigrates" (that's the word that comes) or "tears apart" DNA.

However, sea  salt needs to have iodine with it. If Stargal uses iodized sea salt, it can help to detox something in her system.

We are given that she can use EXTRA salt (as long as it's the iodized sea salt).

Medicine has been correct in always looking for the "next" helpful things... and so there's constant progress with thiings.

Iodized table salt was the only thing around for a long time, and it was better to have the iodine than not, but now, there is a new form (correctly iodized sea salt), and it's NOT TOXIC, at all. So far, I haven't yet found a place or an amount of this particular (Hain's) iodized sea salt that is toxic.

So back to salt, related specifically to Stargal.

On the "salt" page, we needed to follow the link to Extracellular Fluid, because that is what Stargal is needing as another piece.

Here, a few paragraphs down, it's just plain "sodium" that's coming up...
When we follow that link ("sodium"), we end up on a "Homeostasis" page, at a heading called "Extracellular sodium concentration", and that's helpful as well... equally relevant to all the things today.

Here, the sentence that stands out is:
"... to form an octapeptide known as angiotensin II"
So now we need to check on the Angiotensin II, as that feels like a "that's it for here. Got it."

"Angiotensin IV is a hexapeptide that, like angiotensin III, has some lesser activity."
... but here, it's actually the Angiotensin IV that's coming up as very incorrect, but it will know what to do after we check the renin-angiotensin diagram: https://en.wikipedia.org/wiki/Angiotensin#/media/File:Renin-angiotensin-aldosterone_system.png

For Stargal, on this diagram, we are given that when she gets to the Angiotensin II (right smack dab in the middle of the diagram), she didn't know what to do, and invented a really unique workaround. Very creative... but NO angiotensin IV!

Somehow, she backtracked to the Angiotensin, and then went the wrong way around (incorrect direction), where normally the flow goes from the "Water and Salt retention", and ends up back at the kidneys...

We look up Angiotensin II in the gene map database:

Here, there are two that come up:

First, there's the one that's very near the PRCP gene, on Chromsome 11: https://www.omim.org/search/?index=geneMap&start=1&search=PRCP&limit=10
Chromosome: 11
Genomic Start: 11:82,822,939
Cyto Location: 11q14.1  
Gene/Locus: PRCP, PCP
Gene/Locus Name: Prolylcarboxypeptidase (angiotensinase C)  
... but the one that is really helpful is the ACE1 gene on chromosome 17: https://www.omim.org/search/?index=geneMap&start=1&limit=10&search=ACE1
Chromosome: 17
Genomic Start: 17:63,477,060
Cyto Location: 17q23.3
Gene/Locus: ACE, DCP1, ACE1, MVCD3, ICH
Gene/Locus Name: Angiotensin I converting enzyme (dipeptidyl carboxypeptidase-1)
Gene/Locus MIM Number: 106180
Phenotype: {Microvascular complications of diabetes 3}
There are several phenotypes listed, but the one that is most helpful today is the "Microvascular complications of..." phenotype.

For Stargal, the "microvascular complications" piece applies (even though there isn't currently any diabetes 3).  

What's relevant, however, is that Stargal has been having some pretty significant issues with her eyes. When I became aware that the pattern looks like "retinal detachment", Stargal immediately confirmed that there is a history of retinal detachment in her family. Somehow, this gene is relevant.

The "microvascular" insufficiency comes up as affecting the generating of impurities in the eyes. What it means is that some fairly significant toxins are building up and affecting the eyes, and the net result is the muscles are trying to detach.

The enzymes aren't correct, but that's a result of the genes.

That's enough for today. (We started by looking at salt, and ended up at Angiotensin II, and found a gene that is highly relevant to retinal detachment. Interesting!)

Next, we look at just a few more practical ways for Stargal to make adjustments in her lifestyle, to help things along:

She doesn’t get outside much, but more fresh air would really help, and going for a longer walk or hike somewhere, will be helpful.

Also, at this time, potatoes will help her.

It seems that potatoes have a form of non-heme iron, which is also very core to restless legs syndrome, and may help Stargal with that.

Actually, baking the potatoes accentuates or improves the absorption of the iron, or something like that (... and yes, that includes potato chips!) Her younger son also seems to be deficient in iron, and potatoes (especially baked), will help him as well.

There something in the genes, then, because they're both affected, and it's not just because they eat the same foods.  

Also, olive oil comes up as helpful at this time. (Cold-pressed, first pressed... and organic, if possible. Spectrum brand "has it together".)

And there's one more thing that would be really helpful... but that won't be possible just yet. It’s Fish. Any fish!!!

However, there's a significant conflict there... Stargal, and one of her sons as well, has a real aversion to fish. (We've already previously discovered a connection between the fish and the DNA, but we haven't followed that thread yet.)

Just the same, you might like to know that the "aversion" is a self-protective mechanism, and it's related to a gene! Apparently, if there is enough fish in the diet, then the brain won't function properly, so the body knows this, and says "too bad, I don't like fish!"

... so that will probably come up another time again!

(published 07/15/2017)
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   06/22/2017  ~  Salt… or rather, Sodium Chloride
 
 

06/22/2017

Salt… or rather, Sodium Chloride
Consultation for YankeeDancer, a 78-year old female

Background: YankeeDancer recently saw a cardiologist; her EKG was normal, and her echocardiogram was  also normal. However, her blood pressure, which is usually high (and which she takes medication for), was higher than normal, due to some stressful circumstances in her life.

Around the time of the bigger stress, it was up to something like 230/110 at the doctor's office (a little higher as well because YankeeDancer has "white coat syndrome").

So, her doctor added another (a third) medicine for Blood pressure.

We began our consultation today by looking up her blood pressure medications. We haven't done this as of yet, and so it determined the direction of today's consultation.

She had already been taking:
     Bystolic 10 mg
     Indapamide 1.25 (Lozal)  

The new one that was added:
     Valsartan 160 mg
This one was added just this month, and was intended for only a few months.

Here's what came up:

The Bystolic has been doing nice things, and should be continued for now.      

Valsartan, however, immediately came up as "not correct" ... for her.

It's an angiotensin II receptor antagonist... and she does that well on her own. The Valsartan comes up as aggravating something that's borderline... and that "something" would be congestive heart failure. Not big-time just now, but definitely something you want to take care with...

In the meantime, the Lozal (Indapamide) is a thiazide-like diuretic, and that is EXACTLY what she has needed. It will decrease the swelling, as well as the borderline congestive heart failure, which is also new, since beginning the Valsartin.      

To explain more clearly: YankeeDancer has been making the angiotensin receptor antagonists well... (using the other BP medication Bystolic... which was comfortable for this).

However, the Valsartan is "taking over that functionality", so YankeeDancer can't begin to make it (the angiotensin receptor antagonists) on her own.

What happens then is that the genes become switched off... and then she would lose her own ability to make the angiotensin receptor antagonists... and what's important here is that this feels like it would be long-term.

We suggested that she work with her doctor to decrease the dosage of the Valsartan gradually, since her body needs to take over the production of the angiotensin receptor antagonists again, and decreasing it gradually will stimulate that.

She's only been on it a short time, so she can still re-connect the genes.
(I didn't need to work directly with these genes today, as we've already looked at them previously.)

What happened is that in explaining this all, YankeeDancer's body became aware of what we could call "the corrected DNA recipe", and it will be okay... no damage done, and YankeeDancer will begin making  the angiotensin receptor antagonists again.

So here are a few more details for all of this:


It's interesting to note that Valsartan is actually used for CHF sometimes... but in this case, it was aggravating it.

And even more interestingly, there is another place on the Valsartan page that states:
"There is contradictory evidence with regard to treating people with heart failure with a combination of an angiotensin receptor blocker like valsartan and an angiotensin-converting enzyme inhibitor, with two major clinical trials (CHARM-additive and ValHeFt) showing a reduction in death, and two others (VALIANT and ONTARGET) showing no benefits, and more adverse effects including heart attacks."
Bingo!!! It turns out that YankeeDancer was one of those here who is prone to the "more adverse effects" scenario.

And let's go a bit farther, and actually look at the chemical structure of Valsartan:  https://en.wikipedia.org/wiki/Valsartan#/media/File:Valsartan_ball-and-stick.png      

So there are two places where it's off:
The lower left-hand piece, is incorrect... i.e., the medicine (the structure of Valsartan) itself is "off" and isn't helping (and in this case, that seems to be true for some others as well, not just for YankeeDancer).

And on the right-hand side of the diagram at the middle, the pentagon-with-carbon is completely wrong, and undoes many good things that are correct in YankeeDancer.
(Yes, it would be helpful if I knew how to describe the chemistry better, but it's easy to know when it's NOT correct... no matter the description!)      

The Indapamide, on the other hand, is really helpful.

And the chemical structure for the Indapamide is actually helpful to look at as well: https://en.wikipedia.org/wiki/Indapamide#/media/File:Indapamide.svg
For YankeeDancer, this structure comes with an something that says "I know what to do. This is right."      

Next, it was time to check YankeeDancer's OWN energy for the Angiotensin, since that is something that is not correct, but it helps ... re kidneys, and fluid reabsorption.

This isn't yet the key piece that we need, but we'll look here for today, because the angiotensin was coming up as "working" already... However, there are other parts of this diagram we need to check: https://en.wikipedia.org/wiki/Renin%E2%80%93angiotensin_system      

"The renin–angiotensin system (RAS) or the renin–angiotensin–aldosterone system (RAAS) is a hormone system that is involved in the regulation of the plasma sodium concentration and arterial blood pressure."      

This is part of every human body.

For YankeeDancer, the following sentence comes up as the big thing to check today:
"When the plasma sodium concentration is lower than normal..."
Please note that YankeeDancer doesn't add salt to anything, re: her high blood pressure, and she also tries to avoid salty things.      

However, her entire renin production is too low, because she has reduced salt below normal!

What's coming is (and this is for everyone!):
"The human body needs sodium. There is a lot of chemistry that needs to happen because of sodium."
The body needs salt.
... and yes, we also know that "salt may be harmful." It  does mess up a lot of chemistry, but before you jump to conclusions, let's look at what is actually "marketed" as salt ...
We check "Sodium Chloride", the "usual" version of salt: https://en.wikipedia.org/wiki/Sodium_chloride

On this page, you can zoom to see the diagram of the structure: https://en.wikipedia.org/wiki/Sodium_chloride#/media/File:NaCl_polyhedra.png
...  and yes, "it's not nice".

But in looking at the structure, you can see WHY the sodium chloride version of salt is difficult... or to some, harmful.

It's a lattice structure that has zero "give". It's bulky... clunky... and the body isn't familiar with how to break it down.      

Back on the sodium chloride page, just above the "contents" box, you may read the last paragraph:
"Sodium is an essential nutrient for human health via its role as an electrolyte and osmotic solute."
Also:
"The World Health Organization recommends that adults should consume less than 2,000 mg of sodium, equivalent to 5 grams of salt per day."
For YankeeDancer, I know that the next piece we need is way down in the section entitled "Non-dietary uses": https://en.wikipedia.org/wiki/Sodium_chloride#Non-dietary_uses

Here we read that:
"Only about 6% of the salt manufactured in the world is used in food. Of the remainder ...  6% is used in agriculture."
Somehow, there's something here.

As I keep following the information, what comes is that over time, YankeeDancer's system has been processing every last bit of sodium chloride in the packaging of substances.  

For YankeeDancer, we need to reach to find where the difficulty is... and it has something to do with fresh food that is wrapped in some form of casing, often sealed.
This comes up as the nice bags she has sealed fresh food and other food stuff in... (Most of us have ziplock, hefty, glad-lock bags, etc., in our kitchens, don't we?) ... and there is sodium chloride product "left around"  from the manufacturing process.  
So now, if you keep reading in Wikipedia, you'll see that:
"The rest (68%) is used for manufacturing and other industrial processes"
Another "bingo!"
 It is exactly this that has been aggravating YankeeDancer...
... and it comes up that this may well be a reason why many people have "salt issues"... even those who don't have high blood pressure.

So what comes up is that each time YankeeDancer is using fresh-wrapped veggies, etc., "the bag brings the chemical through the sinuses". FYI, YankeeDancer has sinus issues as well.

In other words, salt is used to process many things, and some plastic bags as well...

... and there is something about the chemical ending up in the sinuses... and not the sodium, but the chloride.

Another way of saying this is that there is an allergy to sodium chloride...  for YankeeDancer, and this is the root (of the sinus issues... not to mention the blood pressure).  

FYI, if you're wrapping food, Saran Wrap gets it correct, while other brands don't ... yet.   

To continue: "The rest (68%) is used for manufacturing and other industrial processes, and sodium chloride is one of the largest inorganic raw materials used by volume. Its major chemical products are caustic soda and CHLORINE, which are separated by the electrolysis of a pure brine solution. These are used in the manufacture of PVC, PLASTICS, paper pulp and many other inorganic and organic compounds.
It was "plastics" that kept coming up... thus the "wrapping" of the food.
The source of the caustic fume, though, was actually the "chlorine"

So I guess I shouldn't have been too surprised when YankeeDancer told me that she had owned a home with a swimming pool, for 25 years!

As a result of this, she was near chlorine for long periods of time, especially when handling anything even remotely carrying chlorine (related to the swimming pool).

So the issue with salt (for many people) isn't even about "sodium chloride" directly... it's the "chlorine" issue!
There are many different sources of "chlorine", and owning a swimming pool is just one possibility.

And even though the excerpt from Wikipedia above specifies "chlorine", lest you wonder whether chloride (as in sodium chloride) and chlorine are even related, here's a little bit more information:


There, you'll find that:
"Chlorine is a chemical element with symbol Cl and atomic number 17"
"The most common compound of chlorine, sodium chloride (common salt), has been known since ancient times."
"Because of its great reactivity, all chlorine in the Earth's crust is in the form of ionic chloride compounds, which includes table salt. "
It's the word "reactivity" that comes up as necessary for us to understand... it's reactivity makes it generally unstable.
... and this is the "chloride" we're talking about, not the sodium!

So to reiterate, with sodium chloride, it's not the "sodium" that's the issue... it's the overexposure in our current-day commercial lives to "chloride".

So, back to Salt... but not the sodium chloride version!!!
Salt is necessary!
Sea salt is nicer than sodium chloride, but is not quite the correct thing yet.

The "fad" or movement towards using sea salt is really a great thing...
... but the IODIZING is the next piece of that.
The iodine works really nicely with the sea salt, and it's highly necessary.

So for YankeeDancer, iodized sea salt may be added to her diet, EVEN GENEROUSLY.

Please note, that while there may be generalizations, everyone is totally unique! For YankeeDancer, and for most people, iodized sea salt is "the next piece" for now, but there may well be exceptions.

And if you're looking at iodized sea salt, there aren't too many versions of iodized sea salt available yet, but of those that ARE available, "HAIN" makes the one that's perfect, and it's usable to the human body because it's "fine"... they crystals are small, and so digest well. (The other major version doesn't have anything close to enough iodine... and somehow, salt plus [significant quantities of] iodine together are "correct".) Another note: If you can't find the Hain IODIZED sea salt, Walmart will mail-order it (inexpensively)... and then may actually begin carrying it for a while in the store where you ordered it.

Hain iodized sea salt does not  cause high blood pressure! (I haven't yet found any exceptions to this, but that doesn't mean they don't exist, because everyone is unique, and you may have a gene that does something really unique!) So in addition, (Hain) iodized sea salt actually brings health benefits for most people, and for some individuals, it may even lower blood pressure.

(The other brand of iodized sea salt I've found has rather large crystals, and that happens to compete with chloride in other foods, so it doesn't have the same health benefits as the Hain version, and can, as with table salt, aggravate the sodium chloride picture.)

We're leaving this with:
YankeeDancer will stop using plastic wrap for wrapping fresh, raw food. (She can store more things in containers, rather than whatever version of ziplock bags she was using.)

Once she has the correct salt and this begins correcting itself, then the old sodium chloride will release and will begin moving from the skin as well as from the arteries.

So I just got new information... and it turns out that sodium chloride (or rather, chlorine) has brought "clogs" for YankeeDancer.
I'm not sure just right now what the direct connection is, but it's there... probably via the extended long-time high blood pressure...

So related to the chorine (and salt), the saturated fats had deposited long ago on the walls of her blood vessels, and that snagged more deposits, and the deposits wouldn't let go... in the past. Now they may begin softening.  

We may look at the Renin–angiotensin system for YankeeDancer another time... we only got as far as the first sentence that said "When the plasma sodium concentration is lower than normal ..."  If we have time, we'll also look up some of these things in the gene map database.

(published 07/14/2017)
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   07/20/2017  ~  A series of loops… and Olive Oil to the rescue
 
 

07/20/2017

A series of loops… and Olive Oil to the rescue
Consultation for Rainbow, a 57-year old female

CONSULTATION NOTES:

Today, I was taking a look at Rainbow's most recent bloodwork. Bloodwork is always helpful, because it allows me to find "values" that help with find information, and sometimes gives us another "in" or "route" for looking at something.

The blood work was done on 6/21/2017.

The serum glucose was high. (It was 101, and the range is 65 - 99; this one was okay in her 2015 bloodwork.)

Total cholesterol is high, and has gone up since her 2015 bloodwork. (It was already elevated in 2015)
LDL cholesterol is also high, and has gone up since her 2015 bloodwork. (it was already elevated in 2015)

The hematocrit is in the normal range, but it doesn't feel correct either. This is by way of saying that the value reported is fine, but something is "off".

What it feels like is that some part of the urinary system isn't "correcting yet", i.e., removing old by-products of something related to iron. This comes up as the kidneys doing something incorrectly. And the bilirubin is also way far off. However, in finding this piece, it also can begin to correct itself.

The WBC's are in the normal range, but something is "off". I am very aware here that the immune system is not doing everything correctly.

What it feels like is that SOME of the WBC's are unformed... and they don't know which type to be. This seems to be inherited... and it's coming up as something in "the genes." (They "didn't get the correct recipe".)

As I look at the more specific values for the white blood cells, it's the Basophils that come up.

The number is "0". This is considered normal (range of absolute Basophils is 0 - 0.2) , but it shouldn't be 0... or at least, not here, for Rainbow, just right now.

The "granulocytes" are also coming up. The report is looking at "Immature granulocytes", but it's not that only the immature ones that are off, it's just plain "granulocytes". Something is going on there, which needs an update to connect with a much more corrected recipe.

Rainbow has something going on that is similar to another client I've recently worked with, and knowing we've already looked at this, I can go straight to the piece that's needed: The Adaptive Immune System.


Right at the beginning, there are two things that are relevant to Rainbow:
"The adaptive immune system, also known as the acquired immune system ...  is a subsystem of the overall immune system that is composed of highly specialized, systemic cells and processes that eliminate pathogens or prevent their growth."

... and ...

"Adaptive immunity creates immunological memory after an initial response to a specific pathogen, and leads to an enhanced response to subsequent encounters with that pathogen."
It's the "enhanced response to subsequent encounters with that pathogen" that's necessary to check, as here, there seems to be a bigger immune response to pathogens (in general), than is usual for many others. This means that the body goes into fight-or-flight, which, if you studied chemistry or biology, you might recognize that this means that the adrenaline or nor-adrenaline (here, it's the nor-adrenaline) comes to the rescue, and alerts all systems to "rev up", so the heart begins to race and the system goes haywire (and Rainbow keeps on having "jumpiness" and feeling anxious).

This is in response to the kidneys.

Alright, so we have an auto-immune response that keeps happening.

Are there pathogens anywhere near the kidneys? Yes, but not actually as you might suspect... not bacteria, and not what you might consider a urinary tract infection.
A virus, though, which means the body keeps trying to eliminate it.

Viruses can actually underlie many things in the human body, and can be present in a very ongoing and long-term way.

So just to give help you remember that you already know some of this, here's another bit of information: https://en.wikipedia.org/wiki/Virus#Effects_on_the_host_cell
"Some viruses cause no apparent changes to the infected cell. Cells in which the virus is latent and inactive show few signs of infection and often function normally. This causes persistent infections and the virus is often dormant for many months or years. This is often the case with herpes viruses. Some viruses, such as Epstein–Barr virus, can cause cells to proliferate without causing malignancy, while others, such as papillomaviruses, are established causes of cancer.
So here we find an important piece of Rainbow's very long puzzle. (Some people have many puzzle pieces that are hidden away than some others.)

I've already known that there is autoimmune disease happening, and that the kidneys aren't functioning correctly. That's been there several times. Recently, however, we've begun going deeper through the body systems, and into genes and other proteins directly, so we're coming to a new level of this.

It's not cancer, though, and that's helpful, but there is a propagation of something similar.

We're going to leave that piece here for today (but the kidneys will come back in as part of another equation, though.)

Back to the other bloodwork and lab work that was done:

The MCH is low, but more about that later.

The vitamin D levels were low (25.1, where the range should be 30 - 100).
This is interesting, because Rainbow has, in the past, been taking so much vitamin D that her system should have stored a lot of it away... and she has also made a point of taking in sunshine, deliberately exposing skin to the sunshine (at times when there's much less ultraviolet light there), and including through the wintertime, now that she is aware of this.

But she isn't making vitamin D... as she hasn't yet rearranged her body chemistry to figure out why she doesn't have enough.

Even as a child, as I scan her lovely photos of the cute young kid that she was, even there, I know that she's not making her vitamin D. It's in the genes, then.

And yes, the doctors and researchers are very accurate: Vitamin D underlies many things in the body.

As we continue with the vitamin D, for Rainbow, something is there related to a version of OXYGEN. It's coming up related to using her muscles many times (not only exercising, but just general use), and the tissue not getting enough. The system doesn't know how to bring it to the brain.

We're not talking about oxygen... the "not getting enough" and the "how to bring it to the brain"... but we're talking about energy... and so here we go: Here's where some of the pieces come together, to complete a picture. We've come full circle.

We were looking at Vitamin D production, and came back to something that we had already looked at, back in November of 2016:

ADP ... not ATP, but a different part of the same issue:

ADP is Adenosine Diphosphate. Most people know about ATP, or Adenosine Triphosphate, since that is known as the "molecular unit of currency" of intracellular energy transfer, or you might like to call it "the powerhouse of the cell".

Back in November of 2016, we found some things... and fixed them, but Rainbow sometimes doesn't manage to keep all the new versions of things, because so many pieces are "off" for her, so we have to find many different ways to approach something... and eventually, she does figure out the new version.

So at that time, we got to the ADP via... guess what? Her kidneys! Creatine Kinase, to be more specific:

"CK catalyses the conversion of creatine and utilizes adenosine triphosphate (ATP) to create phosphocreatine (PCr) and adenosine diphosphate (ADP)"
At that time, we already knew (I'll quote from my previous notes here...) that:
"Rainbow's version of the ADP was wrong and strongly wrong... the 5 carbon wasn't there (was missing ... sometimes... in 3 cases)"
That took us to ATP, and also "energy" in the form of "sugar"... and came up as related to a change in diet... which came when Rainbow had a kidney stone, and decided to go on a diet with less acidity, as well as deliberately alkalizing for several years (including the so-greatly-incorrect alkaline water.)

BINGO!

So what comes is:
"How can the body use the amino acids when it's so very alkaline?"
Please understand that everything is chemistry, and the human body is made from many, many chemical reactions.
... and for correct chemical reactions to happen, the chemistry must first have the ingredients.

Each and every single amino acid has an ACIDIC carboxyl group, and an ALKALINE amine group, and it is the simple chemistry between those two (i.e., a chemical reaction) that moves the amino acids together to be an entire chain... i.e., to build the very protein that your genes are giving you the recipes for.

If you can't do the "acidic" part, then your amino acids "can't hold hands" and build the protein... or proteins ... MANY of them.

So even when we helped Rainbow to find corrected versions of the genes, the chemistry wasn't working, and the very proteins that the genes are building couldn't happen correctly. They don't "Bend".

Proteins working correctly is all about the very unique SHAPE of each protein.
If the shape isn't correct, it doesn't work.

So here is one of Rainbow's very big pieces.

Unfortunately, it's not quite that simple: Please note that we've actually looked at the acidity piece before, but not from this core perspective.

We've actually talked about putting more acidity back into the diet, including a bit of "junk food"...  ("Hooray!", goes Rainbow's energy.)

We had already taken a look specifically at vinegar during the 5/19/2017 consultation, related to acidity.

At that time, however, it was simply "an idea". The chemistry wouldn't have used it well, because other things were in the way.

We're still not quite there... her body doesn't make sense of this yet. Why? Probably because something else would get mixed up... and if she added back acidity at this time, just "as is" at the moment, the kidney stones might come back. So we'll have to find a different solution for now.

Notice all the "loops" here...  "Here's a solution, but I can't use, because of THIS." "Okay, here's a way to help "THIS"... but then this other piece is impacted... "

So we'll need to look at the genes, to find a way around this, and to find more places where we can interrupt all the loops, and make something different, so that her chemistry can figure it out, and begin making polypeptide chains, as it's meant to do.
(The polypeptide chains are the amino acids holding hands in order to make protein.)

So the other piece here is: "Is the protein in her diet sufficient?"
... and although we've been working on that piece as well, the body doesn't have enough.

Adding protein creates another "loop"... both for the kidneys, and for the cholesterol...

Okay, to be aware of this is helpful. Each time we know more of the pieces, there is progress, and other pieces can begin to fill in.

For now, we're going to look at another blood value that was off, the MCH, which was just a tiny bit low. (Hers is 26.0, and the range is 26.6 to 33.0)


Mean corpuscular hemoglobin:
"The mean corpuscular hemoglobin (MCH), or "mean cell hemoglobin" (MCH), is the average mass of hemoglobin per red blood cell in a sample of blood. It is reported as part of a standard complete blood count. MCH value is diminished in hypochromic anemias."
Needless to say, the "hypochromic anemias" are coming up. (Of course it is! The MCH was on the low side!)

"Hypochromic anemia is a generic term for any type of anemia in which the red blood cells (erythrocytes) are paler than normal."
also
"Red blood cells will also be small (microcytic) ... The most common causes of this kind of anemia are iron deficiency and ... "
... and it is the iron deficiency that's coming up: https://en.wikipedia.org/wiki/Iron_deficiency

There is a diagram of Heme b, or Iron in heme: https://en.wikipedia.org/wiki/Iron_deficiency#/media/File:Heme_b.svg

It's almost there, but not quite. It's the oxygen, and that's something else that has come up again and again...

As I look at the diagram, this time it's getting there... there is ONE single carboxyl group at the bottom (that's the oxygen with the double bond, and the OH there), on the left side, which isn't yet working correctly. She's getting there, though.

A piece that comes with the oxygen is that "It hurts to think". Rainbow agrees, and has often said that there are times when it feels like that. She says today, "It feels sometimes as if, if I need to think any more, my body can't do it." (Her words were closer to "I'll just explode"... but you get the idea.)

Another comment on the oxygen: So Rainbow notes here that she has always been a shallow breather, and has always been aware of that.

Anyway, we're trying to move on, to see if we can find a way to get PAST all of the big circles, in order to break the cycle.

One of the questions that we need to ask, especially in a case like this, is "What is everyone else eating, that I am NOT eating"... or, "As a child, what did many others do that I missed?"

For Rainbow, there are several elements, and one is that she didn't eat meat (except chicken) when she was little. The fat wouldn't digest well (not that she knew that, but her little body decided to dislike it), so she didn't eat it. It would have made her think more, as the human body loves "brain food"... cholesterol.

Oh boy, you didn't understand? We need cholesterol too! (There will be more about that in other consultations with others.)
No fat, no big enzymes.
... and without that, nothing works.

How many enzymes does the human body make?
"To date, approximately 75,000 enzymes are thought to exist in the human body."
Is that accurate? Not quite... I think they're overlapping many of their definitions, but we make plenty, and it's a REALLY big number!

And, there's much more info in Wikipedia, but we'll keep it really simple for just now.

"Enzymes accelerate chemical reactions."
Ah... we're back to the chemistry again! Imagine that!!! ... and enzymes are made of what? Protein... and amino acids that need to "hold hands" with each other!!!

So for Rainbow, there's actually another fairly decent piece here: Her body doesn't know how to digest fat, but it's often trying these days, since she's been using organic olive oil (cold pressed, first-pressed [Spectrum brand], and then also NOT heated). This piece can help her nicely, NOW, after many years of avoiding gluten (because she had an auto-immune response to it), and eating healthy food. Her digestive tract will respond differently to gluten again, when she adds back organic flour to begin with, and helps it along with olive oil.

You're probably thinking about Italians right now... They digest the meat easily, then, because they add lots of olive oil. There you have it!

So are we talking about fat, or meat protein, or gluten, or enzymes, or chemistry here? Which one?
They are all intertwined. One big puzzle piece, and many others can fit themselves around. Even the iron can, and the MCH values as well, because the oxygen was way off because the enzymes weren't there very well... and oxygen and iron are intertwined, along with all the organs.

What will Rainbow be doing differently?
Just adding a bit more happy fat to things (the organic olive oil), and now putting back a bit of organic flour, occasionally, using the olive oil so that her system will tolerate it.

Enough for today.

(published 07/21/2017)
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